|
| | INCB28060 Dihydrochloride Basic information |
| Product Name: | INCB28060 Dihydrochloride | | Synonyms: | 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride;INCB28060 2HCl;INCB28060 Dihydrochloride;Capmatinib 2HCl;INC-280 2HCl;Capmatinib Dihydrochloride;Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2);Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice | | CAS: | 1197376-85-4 | | MF: | C23H18ClFN6O | | MW: | 448.89 | | EINECS: | 695-736-8 | | Product Categories: | API;API | | Mol File: | 1197376-85-4.mol |  |
| | INCB28060 Dihydrochloride Chemical Properties |
| | INCB28060 Dihydrochloride Usage And Synthesis |
| Description | INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM. | | Uses | INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro. |
| | INCB28060 Dihydrochloride Preparation Products And Raw materials |
|
