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| | Revefenacin Basic information |
| Product Name: | Revefenacin | | Synonyms: | GSK1160724;CPDD1221;Revefenacin / TD4208;Revefenacin:TD-4208:GSK-1160724;biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-ylester;TD 4208;TD4208;1-[2-[[4-[(4-carbamoylpiperidin-1-yl)methyl]benzoyl]-methylamino]ethyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate;Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[2-[[4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]benzoyl]methylamino]ethyl]-4-piperidinyl ester | | CAS: | 864750-70-9 | | MF: | C35H43N5O4 | | MW: | 597.75 | | EINECS: | | | Product Categories: | | | Mol File: | 864750-70-9.mol |  |
| | Revefenacin Chemical Properties |
| Boiling point | 777.5±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 125 mg/mL (209.12 mM) | | pka | 13.34±0.70(Predicted) | | InChIKey | FYDWDCIFZSGNBU-UHFFFAOYSA-N | | SMILES | C(OC1CCN(CCN(C(=O)C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)C)CC1)(=O)NC1=CC=CC=C1C1=CC=CC=C1 |
| | Revefenacin Usage And Synthesis |
| Description | Revefenacin is a synthetic anticholinergic that is prescribed for the treatment of chronic obstructive pulmonary disease (COPD). | | Uses | Revefenacin is used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both. It is an anticholinergic drug that helps the muscles around the airways in the lungs stay relaxed to prevent symptoms such as wheezing, coughing, chest tightness, and shortness of breath. | | Brand name | Yupelri | | Side effects | Common adverse reactions in clinical trials (1%-10%) were headache, nasopharyngitis, upper respiratory tract infection, back pain, bronchitis, dizziness, and hypertension. | | Synthesis | After heating reaction between compound 133 and isocyanates 134, intermediate 135 was obtained after acidification treatment, debenzylation protection and pH alkalinity adjustment, intermediate 137 was obtained by reductive ammonification reaction with 136, de--cbz protection, and then amide product 139 was obtained by condensation reaction, and then prodrug molecule Revefenacin was obtained by reductive ammonification reaction with 140.
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| | Revefenacin Preparation Products And Raw materials |
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