ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives Pyridine-N-oxide

Pyridine-N-oxide

Pyridine-N-oxide Basic information
Product Name:Pyridine-N-oxide
Synonyms:PYRIDINE-1-OXIDE;PYRIDINE-N-OXIDE;1-oxidePyridine;Pyridine oxide;Pyridine N-oxide;pyridineoxide;Pyridin-N-oxid;Pyridine-N-Oxidee
CAS:694-59-7
MF:C5H5NO
MW:95.1
EINECS:211-774-6
Product Categories:important intermediate;C5;Pyridine;Heterocyclic Building Blocks;Pyridines
Mol File:694-59-7.mol
Pyridine-N-oxide Structure
Pyridine-N-oxide Chemical Properties
Melting point 62-67 °C(lit.)
Boiling point 270 °C(lit.)
density 1.1418 (rough estimate)
refractive index 1.5939 (estimate)
Fp 143 °C
storage temp. 2-8°C
form Crystalline Solid, Crystals, and/or Chunks
pka0.79(at 24℃)
color White to brownish
Water Solubility soluble
Sensitive Hygroscopic
Merck 14,7972
BRN 105257
CAS DataBase Reference694-59-7(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 1-oxide(694-59-7)
EPA Substance Registry SystemPyridine, 1-oxide (694-59-7)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22-40-20/21/22
Safety Statements 26-24/25-37/39-36/37/39-22
WGK Germany 3
RTECS UT6410000
F 21
TSCA Yes
HS Code 29333999
MSDS Information
ProviderLanguage
Pyridine-N-oxide English
SigmaAldrich English
ACROS English
ALFA English
Pyridine-N-oxide Usage And Synthesis
Chemical PropertiesWhite to light yellow solid
UsesIntermediate.
UsesPyridine N-Oxide is a useful reagent for the chemical industry, a mild reoxidant that transforms osmium-catalyzed oxidative cyclization. A catalytic agent.
DefinitionChEBI: The pyridine N-oxide derived from the parent pyridine. It is a drug metabolite of the antihypertensive agent pinacidil.
Synthesis Reference(s)Organic Syntheses, Coll. Vol. 4, p. 828, 1963
Tetrahedron Letters, 12, p. 2807, 1971 DOI: 10.1016/S0040-4039(01)97047-9
General DescriptionPyridine N-oxide axle with [2]rotaxanes was synthesized via an anion templated threading-followed-by-stoppering strategy.
HazardProbably flammable and toxic.
Purification MethodsPurify the N-oxide by crystallisation from Et2O and by vacuum sublimation. The picrolonate has m 182-184o. [Katritzky J Chem Soc 2407 1956, Beilstein 20 III/IV 2305, 20/5 V 217.]
Pyridine-N-oxide Preparation Products And Raw materials
Preparation Products4-Aminopyridine-->4-CHLORO-PYRIDINE-2-CARBONITRILE-->4-BENZYLOXY-2(1 H)-PYRIDONE-->4-chloropyridine-->4-Nitropyridine-->2-BROMOPYRIDINE N-OXIDE-->4-chloro-3-(pyridin-2-yl)aniline-->2-PYRAZOL-1-YL-PYRIDINE-->2-CYANO-4-NITROPYRIDINE-->4-Methoxypyridine N-oxide-->4-NITROPICOLINIC ACID-->2-Chloropyridine-->2-Benzylaminopyridine-->2-Pyridinepropanol-->4-METHOXYPYRIDINE-2-CARBOXYLIC ACID-->Sodium Pyrithione-->(R)-tert-Butyl 3-(pyridin-2-ylamino)piperidine-1-carboxylate
2-Pyridinethiol 1-oxide 4-NITROQUINOLINE N-OXIDE 4-Picoline-N-oxide 4-Cyanopyridinium-1-olate [1,2,5]Oxadiazolo[3,4-b]pyridine 1-oxide 2-PICOLINE-N-OXIDE 3-PYRIDINEMETHANOL N-OXIDE Quinoline-N-oxide Pyridine-N-oxide 3-Picoline-N-oxide 4-Nitropyridine N-oxide Nicotinamide-N-oxide 4-[(2-Carboxyphenyl)aminocarbonyl]pyridine 1-oxide 4-Methoxypyridine N-oxide PICOLINIC ACID N-OXIDE Pyridine-4-carboxylic acid N-oxide Nicotinic acid N-oxide 4-PYRIDYLCARBINOL N-OXIDE
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