| | LEPTOMYCIN B Basic information |
| Product Name: | LEPTOMYCIN B | | Synonyms: | ABAR(R);ATS 1287B;ATS1287;CI-940;CL-1957A;ELACTOCIN;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-DIHYDRO-3-METHYL-6-OXO-2H-PYRAN-2-YL]-17-ETHYL-6-HYDROXY-3,5,7,9,11,15-HEXAMETHYL-8-OXO-2,10,12,16,18-NONADECAPENTAENOIC ACID;19-(3,6-DIHYDRO-3-METHYL-6-OXO-2H-PYRAN-2-YL)-17-ETHYL-6-HYDROXY-3,5,7,9,11,15-HEXAMETHYL-8-OXO-2,10,12,16,18-NONADECAPENTAENOIC ACID | | CAS: | 21609-90-5 | | MF: | C13H10BrCl2O2PS | | MW: | 412.07 | | EINECS: | 244-472-8 | | Product Categories: | Nuclear Receptor Signaling | | Mol File: | 21609-90-5.mol |  |
| | LEPTOMYCIN B Chemical Properties |
| Melting point | 71-73 °C | | Boiling point | 444.4±55.0 °C(Predicted) | | density | 1.53 g/cm3 (25 ºC) | | Fp | >100 °C | | storage temp. | 0-6°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | solid | | color | White to Pale Yellow | | Water Solubility | 2.4mg/L(25 ºC) | | BRN | 2152663 | | Stability: | Hygroscopic, Moisture Sensitive | | CAS DataBase Reference | 21609-90-5(CAS DataBase Reference) | | EPA Substance Registry System | Leptophos (21609-90-5) |
| | LEPTOMYCIN B Usage And Synthesis |
| Chemical Properties | Leptophos is a tan, waxy solid | | Uses | Leptomycin B is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory protein Rev at low nanomolar concentrations. It covalently binds to cysteine residue in the center of CRM1/exportin 1 protein. | | Uses | Insecticide. | | Definition | ChEBI: O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate is an organic phosphonate that is phenylphosphonothioic O,O-acid in which the hydroxy groups are substituted by methoxy and 4-bromo-2,5-dichlorophenoxy groups. It is a dichlorobenzene, a member of bromobenzenes, an organic phosphonate and a phosphonic ester. | | General Description | White crystalline or colorless amorphous solid, the technical product is a light tan powder. Used as an insecticide; its use is not permitted in the U.S. | | Reactivity Profile | Organophosphates, such as LEPTOMYCIN B, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. | | Health Hazard | LEPTOMYCIN B is highly toxic; it is capable of causing death or permanent injury by exposure during normal use. | | Fire Hazard | (Non-Specific -- Organophosphorus Pesticide, n.o.s.) Container may explode in heat of fire. Fire may produce irritating or poisonous gases. Decomposes above 356F. Avoid strong alkalies. | | Potential Exposure | A potential danger to those involved
in the manufacture, formulation and application of this
insecticide. Its use is not currently permitted in the United
States of America | | Shipping | UN2783 Organophosphorus pesticides, solid,
toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
UN3464 Organophosphorus compound, solid, toxic, n.o.s,
Hazard Class: 6.1; Labels: 6.1-Poisonous materials,
Technical Name Required | | Incompatibilities | Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, and epoxides. Organophosphates are
susceptible to formation of highly toxic and flammable
phosphine gas in the presence of strong reducing agents
such as hydrides and active metals. Partial oxidation by
oxidizing agents may result in the release of toxic phosphorus oxides. | | Waste Disposal | Small amounts may be treated
with alkali then burned in a landfill. Large quantities
should be incinerated in a unit with effluent gas scrubbing. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticidecontainers. Must be disposed properly by following package label directions or by contacting your local or federal
environmental control agency, or by contacting your
regional EPA office |
| | LEPTOMYCIN B Preparation Products And Raw materials |
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