BUSERELIN

BUSERELIN Basic information

Product Name:	BUSERELIN
Synonyms:	(d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide;(d-ser(tbu)(sup6)-ea(sup10))-lhrh;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone;BUSERELIN;1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-;Buserilin;BUSERELIN PH. EUR.
CAS:	57982-77-1
MF:	C60H86N16O13
MW:	1239.42
EINECS:	261-061-9
Product Categories:	hormones;57982-77-1
Mol File:	57982-77-1.mol

BUSERELIN Chemical Properties

alpha	D20 -40.4° (c = 1 in dimethylacetamide)
Boiling point	845.19°C (rough estimate)
density	1.0711 (rough estimate)
refractive index	1.6200 (estimate)
solubility	Sparingly soluble in water and in dilute acids.
pka	9.82±0.15(Predicted)
form	Solid
color	White to Off-White
Stability:	Hygroscopic
InChIKey	CUWODFFVMXJOKD-UHFFFAOYSA-N

Safety Information

HS Code

2937190000

MSDS Information

BUSERELIN Usage And Synthesis

Chemical Properties	White or slightly yellowish powder, hygroscopic.
Uses	Gonad-stimulating principle.
Definition	ChEBI: Buserelin is an oligopeptide.
Brand name	Suprefact (Hoechst-Roussel).
Clinical Use	Treatment of advanced prostate cancer and endometriosis Pituitary desensitisation in preparation for ovulation induction regimens using gonadotrophins
Metabolism	Metabolic inactivation by peptides occurs in the liver and kidney. The drug is also inactivated by pituitary membrane enzymes. Excreted in the urine and bile as unchanged drug and metabolites.

BUSERELIN Preparation Products And Raw materials

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