ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Aminopyridine Methyl 2-aminonicotinate

Methyl 2-aminonicotinate

Methyl 2-aminonicotinate Basic information
Product Name:Methyl 2-aminonicotinate
Synonyms:Methyl 2-aminonicoti;2- aMinoMethyl nicotinate;2-aMinopyridine-3- forMic acidMethyl ester;Methyl 2-amino-3-pyridinecarboxylate;2-Aminonicotinic Acid Methyl Ester Methyl 2-Aminopyridine-3-carboxylate 2-Aminopyridine-3-carboxylic Acid Methyl Ester;Methyl 2-aMinonicotinate, >95%;Methyl2-aminonicotinate,97%;Methyl 2-aminonicotite
CAS:14667-47-1
MF:C7H8N2O2
MW:152.15
EINECS:681-092-5
Product Categories:pyridine;pharmacetical;Pyridine series;API intermediates
Mol File:14667-47-1.mol
Methyl 2-aminonicotinate Structure
Methyl 2-aminonicotinate Chemical Properties
Melting point 82-86 °C
Boiling point 251.3±20.0 °C(Predicted)
density 1.238±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka4.71±0.36(Predicted)
color White to Almost white
CAS DataBase Reference14667-47-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 22-26-36/37/39
WGK Germany 2
HazardClass IRRITANT
HS Code 2933399990
MSDS Information
ProviderLanguage
ALFA English
Methyl 2-aminonicotinate Usage And Synthesis
Chemical PropertiesOff white powder
UsesMethyl 2-Aminonicotinate is used to prepare 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827)as a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. It is also used to synthesize quinazolinone/quinazoline thione derivatives as phosphodiesterase 7 inhibitors.
Methyl 2-aminonicotinate Preparation Products And Raw materials
Raw materials2-Aminonicotinic acid-->Methanol-->Iodomethane
Preparation Products2-MERCAPTO-3-PHENYLPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE-->Methyl 2-(MethylsulfonaMido)nicotinate
DIETHYL 2-(2-[1-(6-FLUORO-2-PYRIDINYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE 2-AMINO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER DIETHYL 2-AMINO-6-(2-ISONICOTINOYLHYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE METHYL 2-(4-BENZHYDRYLPIPERAZINO)NICOTINATE DIETHYL 2-(2-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-PIPERIDINYLIDENE)HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE METHYL 2-[4-(4-FLUOROPHENYL)PIPERAZINO]NICOTINATE DIETHYL 2-HYDROXY-6-[2-(1-METHYL-4-PIPERIDINYLIDENE)HYDRAZINO]-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-[2-(1-BENZYL-4-PIPERIDINYLIDENE)HYDRAZINO]-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE Methyl 2-aminonicotinate DIETHYL 2-(2-(1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINYLIDENE)HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE METHYL 2-[4-(2-FLUOROPHENYL)PIPERAZINO]NICOTINATE Morniflumate DIETHYL 2-HYDROXY-6-(2-[1-(4-NITROPHENYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-HYDROXY-6-(2-PHENYLHYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE METHYL 2-[4-(2-CHLOROPHENYL)PIPERAZINO]NICOTINATE Clonixeril ISOPROPYL 2-[4-(2-FLUOROPHENYL)PIPERAZINO]NICOTINATE
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