CTX0294885

CTX0294885 Basic information
Product Name:CTX0294885
Synonyms:CTX0294885;2-(5-chloro-2-(4-(piperazin-1-yl)phenylaMino)pyriMidin-4-ylaMino)-N-MethylbenzaMide;2-(5-chloro-2-(4-(piperazin-1-yl)phenylamino)pyrimidin-4-ylamino)-N-methylbenzamide CTX0294885;2-[[5-Chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;CTX-0294885, >=98%;CTX-0294885; CTX 0294885; CTX0294885; CTX 0294885.;CS-1944;CS-1885
CAS:1439934-41-4
MF:C22H24ClN7O
MW:437.93
EINECS:
Product Categories:Inhibitors
Mol File:1439934-41-4.mol
CTX0294885 Structure
CTX0294885 Chemical Properties
density 1.332±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka14.57±0.46(Predicted)
Safety Information
MSDS Information
CTX0294885 Usage And Synthesis
Biological Activityctx-0294885 is a novel bisanilino pyrimidine. it has inhibitory activity towards a wild range of kinases in vitro. ctx-0294885 is capable of capturing more than half of the expressed kinome in mda-mb-231 cells. large-scale ctx-0294885-based affinity purification with lc−ms/ms identifies 235 protein kinases. ctx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. it is further developed into a sepharose-supported kinase capture reagent. ctx-0294885 is a new tool for analysis of kinome signaling networks. [1]
references1. zhang l, holmes ip, hochgräfe f et al. characterization of the novel broad-spectrumkinase inhibitor ctx-0294885 as an affinity reagent for mass spectrometry-basedkinome profiling. j proteome res. 2013 jul 5;12(7):3104-16.
CTX0294885 Preparation Products And Raw materials

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