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| | LL-Z-1640-2 Basic information |
| Product Name: | LL-Z-1640-2 | | Synonyms: | (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione;(5Z)-7-Oxozeaenol;JNK/p38 inhibitor;C292, L 783278;LL-Z-1640-2;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione | | CAS: | 66018-38-0 | | MF: | C19H22O7 | | MW: | 362.37 | | EINECS: | | | Product Categories: | antibiotic | | Mol File: | 66018-38-0.mol |  |
| | LL-Z-1640-2 Chemical Properties |
| storage temp. | Desiccate at -20°C | | solubility | Soluble in DMSO | | form | White solid |
| | LL-Z-1640-2 Usage And Synthesis |
| Uses | LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models. | | Biological Activity | Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro . |
| | LL-Z-1640-2 Preparation Products And Raw materials |
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