ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Basic information
Product Name:1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms:2-Acetyl-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;5-Fluoro-2-hydroxyphenyl(methyl) ketone;5'-Fluoro-2'-hydroxyacetophenone,97%;5’-fluoro-2’-hydroxy-acetophenon;Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-;5'-FLUORO-2'-HYDROXYACETOPHENONE;2-HYDROXY-5-FLUOROACETOPHENONE
CAS:394-32-1
MF:C8H7FO2
MW:154.14
EINECS:206-893-5
Product Categories:Aryl Fluorinated Building Blocks;Building Blocks;C7 to C8;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Acetophenone series;Adehydes, Acetals & Ketones;Fluorine Compounds;Phenols;C7 to C8;Carbonyl Compounds;Ketones;Aromatic Acetophenones & Derivatives (substituted);ketone;(intermediate of nebivolol);Benzenes;Alcohols and Derivatives;Carbonyl Compounds;1
Mol File:394-32-1.mol
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Structure
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties
Melting point 56-58 °C(lit.)
Boiling point 65-66 °C8 mm Hg(lit.)
density 1.1850 (estimate)
Fp 65-66°C/8mm
storage temp. Inert atmosphere,Room Temperature
pka10.17±0.18(Predicted)
form powder to crystal
color White to Gray to Brown
Water Solubility Soluble 0.68 G/L
BRN 2359087
CAS DataBase Reference394-32-1(CAS DataBase Reference)
NIST Chemistry Reference5-Fluoro-2-hydroxyacetophenone(394-32-1)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-37/39-36/37/39
WGK Germany 3
RTECS AM8502300
HazardClass IRRITANT
HS Code 29147000
MSDS Information
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone English
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Usage And Synthesis
Chemical Propertieslight yellow to beige-brown crystals or
Uses5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:
  • 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
  • 3-hydroxy and 3-methoxyflavones
  • 3-hydroxy and 3-methoxy 2-styrylchromones
DefinitionChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.
PreparationPreparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials
Preparation Products2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone-->6-FLUOROCHROMONE-->1-(2-ethoxy-5-fluorophenyl)ethan-1-one-->2-(2-Aanilino-4-thiazolyl)-4-fluorophenol-->1-(2-Hydroxy-5-fluorophenyl)ethanol-->6-FLUOROCHROMONE-3-CARBOXYLIC ACID 97
N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE ETHYL 7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-1-(5-FLUORO-2-HYDROXYPHENYL)PROP-2-EN-1-ONE (E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID N-BENZYL-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-AMINO-6-FLUORO-4-OXO-4H-CHROMENE-3-CARBALDEHYDE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER 6-FLUORO-4-OXO-4H-CHROMENE-3-CARBALDEHYDE OXIME 6-FLUORO-2-METHYL-4-CHROMANONE 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE N-(4-CHLOROBENZYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-FLUORO-3-FORMYLCHROMONE METHYL 2-ETHYL-7-FLUORO-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-Fluoro-4-chromanone METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE
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