N-Chlorophthalimide

N-Chlorophthalimide Basic information
Product Name:N-Chlorophthalimide
Synonyms:N-CHLOROPHTHALIMIDE;ncp;Phthalimidoyl chloride;phthalimide chloride;2-chloro-1h-isoindole-1,3(2h)-dione;Chlorophtalimide;N-Chlorphthalimid;2-Chloro-2H-isoindole-1,3-dione
CAS:3481-09-2
MF:C8H4ClNO2
MW:181.58
EINECS:222-459-8
Product Categories:Chlorination;Halogenation;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Synthetic Organic Chemistry;Carbonyl Compounds;Heterocycles;Cyclic Imides;Organic Building Blocks;3481-09-2
Mol File:3481-09-2.mol
N-Chlorophthalimide Structure
N-Chlorophthalimide Chemical Properties
Melting point 188-198 °C (lit.)
Boiling point 315.1±25.0 °C(Predicted)
density 1.56±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka-3.53±0.20(Predicted)
form powder to crystal
color White to Almost white
InChIKeyWDRFYIPWHMGQPN-UHFFFAOYSA-N
CAS DataBase Reference3481-09-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR 1759
WGK Germany 1
HazardClass 8
PackingGroup II
HS Code 29349990
MSDS Information
ProviderLanguage
SigmaAldrich English
N-Chlorophthalimide Usage And Synthesis
Chemical PropertiesWhite to pale yellow powder
UsesN-Chlorophthalimide may be employed in the synthesis of:
  • α-amino acetal
  • α-amino nitro compounds
  • vicinal diamine
  • α,β-unsaturated vicinal haloamino nitro compound
It may also be used as a chlorination reagent for the synthesis of 3-(methylthio)oxindoles.
General DescriptionN-Chlorophthalimide in anhydrous acetic acid serves as a useful oxidizing reagent for use in various direct titrimetric analyses. N-Chlorophthalimide can be synthesized by reacting phthalimide, t-butyl hypochlorite, water and t-butyl alcohol. It participates in the synthesis of 2-amino-3-benzoyl-α-(methylthio)phenylacetamide.
N-Chlorophthalimide Preparation Products And Raw materials
Preparation ProductsN-(4-Bromobutyl)phthalimide
Methylene Chloride O-Phthalimide Bismaleimide chloramide Calcium chloride 2-methyl-benzenemethanaminhydrochloride Sodium chloride Succinimide Zinc chloride DIALIFOS Choline chloride N-Chlorophthalimide Maleimide Ammonium chloride Oxalyl chloride Potassium chloride Potassium phthalimide 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile

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