O-TOLUIDINE HYDROCHLORIDE

O-TOLUIDINE HYDROCHLORIDE Basic information
Product Name:O-TOLUIDINE HYDROCHLORIDE
Synonyms:o-Tolidine hydroch;o-ToluidineHCL;ORTHO-TOLUIDINEHCL;ORTHO-TOLUIDINEHYDROCHLORIDE;Prilocaine Related Compound A (100 mg) (o-toluidine hydrochloride);Prilocaine Related CoMpound A;Prilocaine EP Impurity B;Prilocaine impurity B
CAS:636-21-5
MF:C7H10ClN
MW:143.61
EINECS:211-252-8
Product Categories:amine
Mol File:636-21-5.mol
O-TOLUIDINE HYDROCHLORIDE Structure
O-TOLUIDINE HYDROCHLORIDE Chemical Properties
Melting point 215-217 °C(lit.)
Boiling point 242 °C
density 1.0968 (rough estimate)
refractive index 1.5760 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form neat
color White to Grey
BRN 3558629
Stability:Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive.
InChIKeyOGVXWEOZQMAAIM-UHFFFAOYSA-N
CAS DataBase Reference636-21-5(CAS DataBase Reference)
EPA Substance Registry Systemo-Toluidine hydrochloride (636-21-5)
Safety Information
Hazard Codes T
Risk Statements 45-20/21/22
Safety Statements 53-36/37/39-45
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS XU7350000
HazardClass 6.1(a)
PackingGroup II
HS Code 2921430000
Hazardous Substances Data636-21-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
O-TOLUIDINE HYDROCHLORIDE Usage And Synthesis
Chemical Propertieswhite crystalline powder
Useso-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of more than 90 dyes and pigments (NCI 1979, IARC 1982, 2000). They are used in acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds and as a photographic dye. o-Toluidine is also used as an intermediate for synthetic rubber and rubber vulcanizing chemicals, pharmaceuticals, and pesticides and as a curing agent in epoxy resin systems. Other minor uses of o-toluidine and its hydrochloride salt are as an intermediate in organic synthesis and as an ingredient in a clinical laboratory reagent for glucose and hemoglobin analyses.
Useso-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A
General DescriptionGreen crystals or white crystalline solid. Melting point 215-217°F. Highly toxic.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileO-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .
Fire HazardFlash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.
Safety ProfileConfirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also o- TOLUIDINE.
Carcinogenicityo-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.
O-TOLUIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials2-METHYLFORMANILIDE-->2-Nitrotoluene-->o-Toluidine
Preparation ProductsOIL YELLOW OB-->1,3-DIPHENYLPROPANETRIONE
2-Chloro-N-(2,6-dimethylphenyl)acetamide 2-Methyl-3-nitrobenzyl chloride REACTIVE BLUE 4 6-CHLOROISATIN [4-CHLORO-2-(1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-PHENYL]-METHYL-AMINE 2-Chloro-6-nitrotoluene N-(4-AMINO-2-METHYLPHENYL)-4-CHLOROPHTHALIMIDE (-)-1-[5-CHLORO-2-(METHYLAMINO)PHENYL]-1,2,3,4-TETRAHYDROISOQUINOLINE,(-)-TARTRATE 2-CHLORO-6-NITROBENZONITRILE 2-(TRICHLOROMETHYL)QUINAZOLIN-4(3H)-ONE 3-Chloro-2-nitrobenzoic acid 2-NITROBENZYL CHLORIDE 2-CHLORO-6-NITROBENZALDEHYDE 4-CHLORO-2-NITROBENZYL CHLORIDE METHYL 4-CHLORO-2-NITROBENZOATE 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 5-Chloro-2-methylene-1,3,3-trimethylindoline 4-Chloro-2-nitrotoluene

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