ChemicalBook Product Catalog API Nervous system drugs Antiparkinson Drugs 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Basic information
Product Name:2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonyms:Piribendyl;2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine;1-(2-Pyrimidyl)-4-piperonylpiperazine;PIRIBEDIL(FORR&DONLY0;PIRIBEDIOL;ET-495;EU-4200;Trivastal
CAS:3605-01-4
MF:C16H18N4O2
MW:298.34
EINECS:222-764-6
Product Categories:Isotope labelled API;API
Mol File:3605-01-4.mol
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Structure
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties
Melting point 98°
Boiling point 439.76°C (rough estimate)
density 1.1183 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka7.17±0.10(Predicted)
form Solid
color White
Merck 14,7493
CAS DataBase Reference3605-01-4(CAS DataBase Reference)
Safety Information
RTECS UV9704000
HS Code 2933.59.8000
ToxicityLD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)
MSDS Information
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorTrivastal, Eutherapie ,France,1969
UsesPiribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.
UsesPiribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impai rment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.
DefinitionChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.
Manufacturing ProcessTo a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.
Therapeutic FunctionVasodilator
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Preparation Products And Raw materials
Raw materials2-Chloropyrimidine-->1-Piperonylpiperazine-->1-Phenyl-1-propanol-->Piperonylic acid-->Piperonyl chloride-->Piperonyl alcohol-->2-(1-Piperazinyl)pyrimidine-->Piperonyl aldehyde
CYCLAZOSIN HYDROCHLORIDE 4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)pyrocatechol hydrochloride hydrate (2:4:1) Pirenoxine Gabapentin Piribedil-d8 Entacapone 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]-7-[(E)-2-PHENYLETHENYL]-7,8-DIHYDRO-5(6H)-QUINAZOLINONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(FURAN-2-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine PIRIBEDIL HYDROCHLORIDE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7-(THIOPHEN-2-YL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-[1,3-BENZODIOXOL-5-YLMETHYL]-1-PIPERAZINYL)PYRIMIDINE MALEATE SALT
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