16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione

16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Basic information
Product Name:16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione
Synonyms:16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione;(8S,10R,13S,14S,16R,17S)-16,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione;(8S,9S,10R,13S,14S,16R,17S)-16,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione;Pregna-1,4-diene-3,11,20-trione, 16,17,21-trihydroxy-, (16α)-;Budesonide Impurity 51;11-Keto-16alpha-hydroxyprednisolone
CAS:3754-05-0
MF:C21H26O6
MW:374.42754
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids
Mol File:3754-05-0.mol
16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Structure
16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Chemical Properties
Melting point >225°C (dec.)
Boiling point 594.8±50.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka11.83±0.70(Predicted)
color White to Off-White
Safety Information
MSDS Information
16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Usage And Synthesis
Chemical PropertiesWhite Solid
UsesA metabolite of Budesonide (B689490), an antiinflammatory agent.
16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Preparation Products And Raw materials
16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Budesonide Impurity 19 IMp. A (EP): 11β,16α,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione (16-Hydroxy- prednisolone) Budesonide Impurity 7 21-Acetoxy-11-oxo-16α,17α-propylMethylenedioxpregna-1,4-diene-3,20-dione (11β,16α)-21-(Acetyloxy)-11,16,17-trihydroxypregna-1,4,14-triene-3,20-dione Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-epoxy-16,17-dihydroxy-, (9β,11β,16α)- Prednisone 17, 21-Diacetate 11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione Budesonide Impurity 11 Budesonide Impurity 18 Budesonide iMpurity 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione Budesonide Impurity 6 (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 21-Dehydro-16α-hydroxy Prednisolone 1,2-Dehydrobudesonide 2,4,6-tripropyl-1,3,5-trioxane

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