(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Basic information
Product Name:(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
Synonyms:(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine;[5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine;[5-Bromo-3-[[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]oxy]pyridin-2-yl]amine;(R)-5-BroMo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylaMine;(R)-5-broMo-3-[1-(2,6-dichloro-3-fluoropehnyl)ethoxy]pyridin-2-aMine;Crizotinib Impurity 3;InterMediate Ⅰof Crizotinib (R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-aMine;2-PyridinaMine, 5-broMo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-
CAS:877399-00-3
MF:C13H10BrCl2FN2O
MW:380.04
EINECS:700-798-7
Product Categories:intermediate;877399-00-3
Mol File:877399-00-3.mol
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Structure
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Chemical Properties
Melting point 107.0 to 111.0 °C
Boiling point 423.4±40.0 °C(Predicted)
density 1.643
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka5.55±0.10(Predicted)
form powder to crystal
color White to Light yellow to Light orange
InChIInChI=1S/C13H10BrCl2FN2O/c1-6(11-8(15)2-3-9(17)12(11)16)20-10-4-7(14)5-19-13(10)18/h2-6H,1H3,(H2,18,19)/t6-/m1/s1
InChIKeyURFUZAZEKBBCEY-ZCFIWIBFSA-N
SMILESC1(N)=NC=C(Br)C=C1O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C
Safety Information
HS Code 2933.39.9200
MSDS Information
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Usage And Synthesis
Chemical PropertiesPale yellow solid
Uses(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is used in preparation of Crizotinib intermediate.
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Preparation Products And Raw materials
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Crizotinib 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Bromisoval Pinaverium bromide [[(2S)-2-ISOPROPYL-5-METHYLCYCLOHEXYL]OXY]ACETIC ACID Tribromobenzene Hydrogen bromide

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