(S)-Ketorolac

(S)-Ketorolac Basic information
Product Name:(S)-Ketorolac
Synonyms:Ketorolac S-IsoMer;Ketorolac impurity 2/Ketorolac S-Isomer;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-;(S)-Ketorolac ISO 9001:2015 REACH;Phosphorousacid,tris(1,5-dimethylethyl)ester
CAS:66635-92-5
MF:C15H13NO3
MW:255.27
EINECS:
Product Categories:Aromatics;Chiral Reagents;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:66635-92-5.mol
(S)-Ketorolac Structure
(S)-Ketorolac Chemical Properties
Melting point 160-167?C
Boiling point 493.2±40.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly
form A crystalline solid
pka4.29±0.20(Predicted)
Safety Information
MSDS Information
(S)-Ketorolac Usage And Synthesis
Description(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.
Chemical PropertiesOff-White Solid
Uses(S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
UsesThe R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
DefinitionChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
(S)-Ketorolac Preparation Products And Raw materials
2,2'-BIPYRROL Ketorolac EP IMpurity G Ketorolac Impurity 43 Ketorolac Impurity 21 Ketorolac tromethamine 4-HYDROXY KETOROLAC Ketorolac Impurity 48 (5-chloro-1H-pyrrol-2-yl)-phenylmethanone Ketorolac Impurity 24 5-Benzoyl-2,3-Dihydro-Lh-Pyrrolizme-L,L-DicarboxyiicAcid,KetoralacTromethamine (R)-(+)-Ketorolac Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide) Ethyl 2-(1H-pyrrol-2-yl)acetate 1-Keto Ketorolac Ketorolac Impurity 31 rac Ketorolac 6-Benzoyl IsoMer Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol) 3-BENZOYLPYRROLE

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