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| | SINOMENINE HYDROCHLORIDE Basic information |
| Product Name: | SINOMENINE HYDROCHLORIDE | | Synonyms: | hydroxy-dimethoxy-methyl-BLAH-azatetracyclo[BLAH]hexadeca-BLAH,BLAH,BLAH,BLAH-tetraenone;Sinomenine Hydrocloride;Cucoline hydrochloride;(9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride;SINOMENINE HYDROCHLORIDE;SINOMENINE HCL;(9α,13α,14α)- 7,8-Didehydro-4-
hydroxy-3,7-diMet;7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl-
9α,13α,14α-Morphinan-6-one Hydrochloride | | CAS: | 6080-33-7 | | MF: | C19H24ClNO4 | | MW: | 365.85 | | EINECS: | | | Product Categories: | Alkaloids;Inhibitors;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;APIs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent | | Mol File: | 6080-33-7.mol |  |
| | SINOMENINE HYDROCHLORIDE Chemical Properties |
| Melting point | 231.0 to 235.0 °C | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: soluble20mg/mL, clear | | form | powder | | color | white to beige | | optical activity | [α]/D -70 to -90°, c = 1 in H2O | | Water Solubility | Soluble to 100 mM in water |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | QD2163000 | | HS Code | 29334900 |
| | SINOMENINE HYDROCHLORIDE Usage And Synthesis |
| Description | Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein. | | Chemical Properties | White Solid | | Uses | Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect. | | Purification Methods | Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.] |
| | SINOMENINE HYDROCHLORIDE Preparation Products And Raw materials |
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