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| | 2-MONOPALMITIN Basic information |
| Product Name: | 2-MONOPALMITIN | | Synonyms: | 2-monopalmitoylglycerol (C16:0);2-O-Hexadecanoylglycerol;2-O-Palmitoylglycerol;2-O-Palmitoyl-L-glycerol;Hexadecanoic acid [2-hydroxy-1-(hydroxymethyl)ethyl] ester;Palmitic acid 2-hydroxy-1-(hydroxymethyl)ethyl ester;2-(1,3-dihydroxypropan-2-yl)hexadecanoic acid compound with 1,3-dihydroxypropan-2-yl palmitate (1:1);2-Hexadecanoylglycerol | | CAS: | 23470-00-0 | | MF: | C19H38O4 | | MW: | 330.5 | | EINECS: | | | Product Categories: | Fatty Acid Derivatives & Lipids;Glycerols;Cannabinoid receptor;SiChem | | Mol File: | 23470-00-0.mol |  |
| | 2-MONOPALMITIN Chemical Properties |
| Melting point | 68-70°C | | Boiling point | 387.92°C (rough estimate) | | density | 0.9708 (rough estimate) | | refractive index | 1.4434 (estimate) | | storage temp. | −20°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | 13.54±0.10(Predicted) | | form | neat | | color | White to Off-White | | BRN | 1796692 |
| Hazard Codes | Xi | | Risk Statements | 43 | | Safety Statements | 36/37 | | WGK Germany | 3 |
| | 2-MONOPALMITIN Usage And Synthesis |
| Description | 2-Arachidonoyl glycerol (2-AG; ) is an endogenous agonist of the CB1 and CB2 cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB1 and CB2 and inhibit adenylyl cyclase. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release. 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity. | | Chemical Properties | White Solid | | Uses | A biomarker of metabolic responses to hepatotoxicants and carcinogens. | | Definition | ChEBI: A 2-monoglyceride where the acyl group is hexadecanoyl (palmitoyl). | | Biological Activity | Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol ((5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester ). Does not bind to CB 1 or CB 2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol. |
| | 2-MONOPALMITIN Preparation Products And Raw materials |
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