ChemicalBook Product Catalog Analytical Chemistry Standard Forensic and veterinary standards P-HYDROXYMETHAMPHETAMINE

P-HYDROXYMETHAMPHETAMINE

P-HYDROXYMETHAMPHETAMINE Basic information
Product Name:P-HYDROXYMETHAMPHETAMINE
Synonyms:1-(p-hydroxyphenyl)-2-methylaminopropane;1-(p-oxyphenyl)-2-methylaminopropan;alpha-(p-hydroxyphenyl)-beta-methylaminopropane;alpha-(p-oxyphenyl)-beta-methylaminopropane;beta-(p-hydroxyphenyl)isopropylmethylamine;beta(p-oxy-phenyl)isopropylmethylamin;epifen;foledrin
CAS:370-14-9
MF:C10H15NO
MW:165.23
EINECS:206-725-0
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:370-14-9.mol
P-HYDROXYMETHAMPHETAMINE Structure
P-HYDROXYMETHAMPHETAMINE Chemical Properties
Melting point 162-163°
Boiling point 293.09°C (rough estimate)
density 1.0203 (rough estimate)
refractive index 1.4820 (estimate)
storage temp. −20°C
solubility Methanol (Slightly)
form neat
pka9.82±0.15(Predicted)
Safety Information
Hazard Codes Xi,T,F
Risk Statements 36/37/38-39/23/24/25-23/24/25-11
Safety Statements 26-36-45-36/37-16-7
WGK Germany 3
RTECS SL8400000
ToxicityLD50 parenteral in mouse: 100mg/kg
MSDS Information
P-HYDROXYMETHAMPHETAMINE Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorPholedrine Sulfate, ZYF Pharm Chemical
UsesAn a-adrenergic agonist. Antihypotensive.
DefinitionChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic FunctionSympathomimetic, Mydriatic, Analeptic, Vasopressor
P-HYDROXYMETHAMPHETAMINE Preparation Products And Raw materials
Raw materialsHydrogen-->4-Methoxyphenylacetone-->Nickel
4-HYDROXYEPHEDRINE HYDROCHLORIDE N-ACETYL-L-PHENYLALANYL-3,5-DIIODO-L-TYROSINE 10,11-Dimethoxystrychnine BZ-TYR-NH2 Ethyl N-acetyl-L-tyrosinate hydrate (+)-Bicuculline Z-TYR-TYR-OH L-LEUCYL-L-TYROSINE N-Glycyl-L-tyrosine Ethyl N-benzoyl-L-tyrosinate N-Acetyl-3,5-diiodo-L-tyrosine D-TUBOCURARINE CHLORIDE DL-LAUDANOSOLINE HYDROBROMIDE TRIHYDRATE N-CBZ-VAL-TYR METHYL ESTER AC-TYR-NH2 (+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE CHLOROACETYL-L-TYROSINE DL-LAUDANOSINE
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