4-Chlorophenylacetone

4-Chlorophenylacetone Basic information
Product Name:4-Chlorophenylacetone
Synonyms:1-chloro-2-(1-methylethenoxy)benzene;1-(p-chlorophenyl)acetone;2-Propanone, 1-(4-chlorophenyl)-;2-Propanone,1-(4-chlorophenyl)-;4-Chlorphenylaceton;P-CHLORO BENZYL METHYL KETONE;(P-CHLOROPHENYL)ACETONE;4'-CHLOROPHENYLACETONE
CAS:5586-88-9
MF:C9H9ClO
MW:168.62
EINECS:226-986-4
Product Categories:Aromatic Ketones (substituted)
Mol File:5586-88-9.mol
4-Chlorophenylacetone Structure
4-Chlorophenylacetone Chemical Properties
Melting point 6-8 °C
Boiling point 132 °C
density 1.151
refractive index 1.5325-1.5345
Fp >110℃
storage temp. Sealed in dry,Room Temperature
form Liquid
color Clear light yellow
CAS DataBase Reference5586-88-9(CAS DataBase Reference)
NIST Chemistry Reference2-Propanone,p-chlorophenyl-(5586-88-9)
Safety Information
Hazard Codes Xn
Risk Statements 22-52
Safety Statements 24/25
HS Code 29147000
MSDS Information
ProviderLanguage
ACROS English
4-Chlorophenylacetone Usage And Synthesis
Chemical Propertiesclear light yellow liquid
Uses4-Chlorophenylacetone is a phenylacetone derivative used in the preparation of biologically active compounds such as anorectic agents.
PreparationAt present, there are three main synthetic routes for 4-chlorophenylacetone. The first is to synthesize 4-chlorophenylacetone with sodium p-chlorobenzenesulfonate and acetone as raw materials, with a yield of about 54%. The second synthesis route is to synthesize 4-chlorophenylacetone with p-chlorobenzenesulfonyl chloride and chloroacetone as raw materials. The third synthesis route is to synthesize 4-chlorophenylacetone from chloroacetone.
Synthesis Reference(s)The Journal of Organic Chemistry, 48, p. 2590, 1983 DOI: 10.1021/jo00163a034
Health HazardWhen it contacts with skin and mucous membrane, 4-chlorophenylacetone will cause inflammation, so pay attention to safety when using 4-chlorophenylacetone. This chemical is harmful to environment. It should be prevented from contacting groundwater, waterways or sewage systems. Without government permission, 4-chlorophenylacetone should not be discharged into the surrounding environment.
4-Chlorophenylacetone Preparation Products And Raw materials
Preparation Products1-(2-Chlorophenyl)acetone-->1-(2,4,6-Trichlorophenyl)propan-2-one
4-Fluorophenylacetone 1,3-Diphenylacetone Acetylacetone 1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHANE-1,2-DIONE 4-[2-(4-CHLOROPHENYL)ACETYL]-1H-PYRROLE-2-CARBONITRILE 4,4'-Dichlorobenzil Phenylacetone 1,2-BIS(4-CHLOROPHENYL)ETHANONE 3,4-Dichlorophenylacetone 4-Methoxyphenylacetone 2,4-Dichlorophenylacetone 4-Chlorophenylacetone 2-(4-CHLOROPHENYL)INDANE-1,3-DIONE 4,4'-DICHLOROBENZOIN 3-(4-CHLORO-PHENYL)-7-HYDROXY-CHROMEN-4-ONE 1-Deuteriopropan-2-one Propiophenone 2,2,2-TRICHLORO-1-(4-[2-(4-CHLOROPHENYL)ACETYL]-1H-PYRROL-2-YL)-1-ETHANONE

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