ChemicalBook Product Catalog Chemical Reagents Organic reagents Amide N-BROMOACETAMIDE

N-BROMOACETAMIDE

N-BROMOACETAMIDE Basic information
Product Name:N-BROMOACETAMIDE
Synonyms:ACETOBROMAMIDE;N-BROMOACETAMIDE (NBA);AcetaMide, N-broMo-;N-Bromoacetamide;N-BROMOACETAMIDE;NBAAcetobromamide;n-bromo-acetamid;2-[2-(dimethylamino)ethoxymethoxy]-N,N-dimethylethanamine
CAS:79-15-2
MF:C2H4BrNO
MW:137.96
EINECS:201-181-0
Product Categories:Bromination;Halogenation;Synthetic Organic Chemistry
Mol File:79-15-2.mol
N-BROMOACETAMIDE Structure
N-BROMOACETAMIDE Chemical Properties
Melting point 102-105°C
Boiling point 127-130 °C(Press: 16 Torr)
density 1.7000 (rough estimate)
refractive index 1.4740 (estimate)
storage temp. -20°C
solubility very slightly in Chloroform
form powder
pka9.41±0.46(Predicted)
color white to yellow
Water Solubility Soluble in water.
Merck 14,1398
BRN 969346
CAS DataBase Reference79-15-2(CAS DataBase Reference)
EPA Substance Registry SystemN-Bromoacetamide (79-15-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR 3261
WGK Germany 3
F 8
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29299090
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
N-BROMOACETAMIDE Usage And Synthesis
UsesAbolishes the rapid inactivation of membrane sodium- and potassium-ion channels.
UsesN-bromoacetamide annihilates the rapid inactivation of membrane sodium-ion channels. Also functions in the kinetics of cardiac sodium ion channels.
General DescriptionWhite powder.
Air & Water ReactionsSoluble in water.
Reactivity ProfileN-BROMOACETAMIDE is sensitive to light, moisture, and heat. . N-BROMOACETAMIDE decomposes rapidly at elevated temperatures, in the presence of moisture and light.
Fire HazardFlash point data are not available for N-BROMOACETAMIDE, but N-BROMOACETAMIDE is probably combustible.
Purification MethodsA possible contaminant is CH3CONBr2. Recrystallise it from CHCl3/hexane (1:1, seed if necessary) or water and dry over CaCl2. It is a brominating agent. [Oliveto & Gerold Org Synth Coll Vol IV 104 1963.] Alternatively, dissolve it in the minimum volume of warm H2O (60o), then cool in an ice bath, collect the crystals and dry them in an anhydrous atmosphere, dissolve in Et2O, chill and evaporate till crystallisation. Dry the crystals in vacuo at 25o, then at 45o (m 108o). Crystallise from CHCl3 (m 103o). Estimate the available Br iodometrically [Buckles et al. J Org Chem 23 483 1958]. [Beilstein 2 H 181, 2 I 82, 2 II 180, 2 III 406, 2 IV 417.]
N-BROMOACETAMIDE Preparation Products And Raw materials
Raw materialsPotassium hydroxide solution
Preparation Products1-Bromo-2-chloroethane-->Bromotriphenylethylene
N1-{2-[(4-CHLORO-2-NITROPHENYL)THIO!PHENYL}-2-BROMOACETAMIDE, TECH N-(1,10-PHENANTHROLIN-5-YL)BROMOACETAMIDE N1-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL!-2-BROMOACETAMIDE, TECH N1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-2-bromoacetamide N-BROMOCAPROLACTAM N1-(5-methyl-1,3,4-thiadiazol-2-yl)-2-bromoacetamide 2-Bromo-2'-(trifluoromethyl)acetanilide N-(4-ACETYLPHENYL)-2-BROMOACETAMIDE 1,3-DIBROMO-5-ETHYL-5-METHYLHYDANTOIN tempo 4-bromoacetamide N1-(4-METHOXY-1,3-BENZOTHIAZOL-2-YL)-2-BROMOACETAMIDE 2-Bromo-3'-(trifluoromethyl)acetanilide N-BROMOSACCHARIN N1-(4-BROMOPHENYL)-2-BROMOACETAMIDE TEXAS RED(R) C5 BROMOACETAMIDE N-(3-ACETYLPHENYL)-2-BROMOACETAMIDE N-(2-benzoylphenyl)-2-bromoacetamide,N1-(2-BENZOYLPHENYL)-2-BROMOACETAMIDE N1-{4-BROMO-3-[4-(TERT-BUTYL)PHENYL!-1H-PYRAZOL-5-YL}-2-BROMOACETAMIDE, TECH
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