Chloromethyl pivalate

Chloromethyl pivalate Basic information

Product Name:	Chloromethyl pivalate
Synonyms:	Chloromethyl 2,2-dimethylpropanoate;Methanol, chloro-, pivalate;Chloromethyl Pivalate , (2,2-Dimethylpropanoic acid chlormetyl ester);ChloroMethyl pivalate, 99+% 100GR;Chloromethyl Trimethylacetate 2,2-Dimethylpropionic Acid Chloromethyl Ester Pivalic Acid Chloromethyl Ester Trimethylacetic Acid Chloromethyl Ester;ChloroMethyl pivalate 97%;Pivalic acid Methyl chloride;hloromethyl pivalate
CAS:	18997-19-8
MF:	C6H11ClO2
MW:	150.6
EINECS:	242-735-1
Product Categories:	Other Products;API;Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Pharmaceutical Intermediates;Phosgene Derivatives;Miscellaneous;Pharmaceutical Intermediate;Esters;Organic Building Blocks;T0001
Mol File:	18997-19-8.mol

Chloromethyl pivalate Chemical Properties

Melting point	<-40°C
Boiling point	146-148 °C (lit.)
density	1.045 g/mL at 25 °C (lit.)
refractive index	n20/D 1.417(lit.)
Fp	104 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Sparingly)
form	Liquid
color	Clear colorless to slightly yellow
Specific Gravity	1.038
Water Solubility	Miscible with most organic solvents. Immiscible with water.
BRN	1560838
InChIKey	GGRHYQCXXYLUTL-UHFFFAOYSA-N
CAS DataBase Reference	18997-19-8(CAS DataBase Reference)
NIST Chemistry Reference	Propanoic acid, 2,2-dimethyl-, chloromethyl ester(18997-19-8)
EPA Substance Registry System	Propanoic acid, 2,2-dimethyl-, chloromethyl ester (18997-19-8)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	10-20/21/22-36/37/38
Safety Statements	16-26-36-41-36/37/39
RIDADR	UN 3272 3/PG 3
WGK Germany	3
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29159000

MSDS Information

Provider	Language
2,2-Dimethylpropanoic acid chloromethyl ester	English
SigmaAldrich	English
ACROS	English
ALFA	English

Chloromethyl pivalate Usage And Synthesis

Chemical Properties	Clear colorless to slightly yellow liquid
Uses	Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.
General Description	Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.

Chloromethyl pivalate Preparation Products And Raw materials

Raw materials

Zinc chloride-->Paraformaldehyde-->Pivaloyl chloride

Preparation Products

PIVALOYLOXYMETHYL 6-AMINOPENICILANATE-->Pivaloyloxymethyl6-(phenylacetamido)penicillanate-->(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate-->Adefovir dipivoxil N6-Hydroxymethyl Impurity-->Adefovir dipivoxil-->1-(PIVALOYLOXYMETHYL)-1H-INDOLE-3-CARBOXYLIC ACID-->Azidomethyl pivalate-->2,2-Dimethylpropanoic acid [[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphinylidene]bis(oxymethylene) ester-->7-Hydroxy-6-methoxy-3-[(pivaloyloxy)methyl]-3,4-dihydroquinazolin-4-one

t-butyl chloroformate DIMETHYLTHEXYLSILYL CHLORIDE Chloromethyl methyl ether 2-Chloro-2-methylpropane Calcium chloride tert-Butyldimethylsilyl chloride Sodium chloride Beclomethasone dipropionate Zinc chloride Choline chloride Chloromethyl pivalate Chloromethyl butyrate Methyl chloroformate Methyl trimethylacetate Oxalyl chloride Methyl propionate Methyl methacrylate Methyl chloroacetate

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