ChemicalBook Product Catalog Pharmaceutical intermediates Bulk Drug Intermediates 4-Bromopyrazole

4-Bromopyrazole

4-Bromopyrazole Basic information
Product Name:4-Bromopyrazole
Synonyms:4-bromo-pyrazol;4-Brompyrazole;Pyrazole, 4-bromo-;4-BROMO-1H-PYRAZOLE;4-BROMOPYRAZOLE;AKOS B001462;93℃-96℃;4-Bromopyrazole,98%
CAS:2075-45-8
MF:C3H3BrN2
MW:146.97
EINECS:
Product Categories:Building Blocks;C3 to C5;Halides;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Azoles;blocks;Bromides;Heterocycles;Pyrazoles & Triazoles;Halogenated;Amines;Aromatics;Organohalides;Pyrazole;CHIRAL CHEMICALS;Pyrazoles & Triazoles;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles;PyrazolesHeterocyclic Building Blocks;API;2075-45-8
Mol File:2075-45-8.mol
4-Bromopyrazole Structure
4-Bromopyrazole Chemical Properties
Melting point 93-96 °C (lit.)
Boiling point 250-260 °C (lit.)
density 1.5979 (rough estimate)
refractive index 1.5260 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform, DMSO, Methanol
form Crystalline Powder
pka12.71±0.50(Predicted)
color White to cream
Water Solubility Slightly soluble in water.
InChIKeyFHZALEJIENDROK-UHFFFAOYSA-N
CAS DataBase Reference2075-45-8(CAS DataBase Reference)
NIST Chemistry Reference1H-pyrazole, 4-bromo-(2075-45-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
RTECS UQ6200000
HazardClass IRRITANT
HS Code 29331990
MSDS Information
ProviderLanguage
SigmaAldrich English
4-Bromopyrazole Usage And Synthesis
Chemical PropertiesWhite to cream crystalline powder
Uses4-Bromopyrazole can be used as starting material employed in a synthesis of 1,4′-bipyrazoles and in suzuki reaction.
UsesAs a mono substituted pyrozole, 4-Bromopyrazole can be used as Inhibitor of human liver alcohol dehydrogenase and used in mutagenicity study with the L-arabinose resistance test of Salmonella typhimurium.
General Description4-Bromopyrazole is a pyrazole derivative. It is reported to react with titanium tetrachloride to afford binary adducts. Mutagenicity of 4-bromopyrazole has been tested using the L-arabinose forward mutation assay of Salmonella typhimurium. It is reported to inhibit the oxidative phosphorylation, the ATP-32P exchange reaction, and energy dependent and independent calcium uptake.
4-Bromopyrazole Preparation Products And Raw materials
Preparation Products1-Methyl-4-pyrazole boronic acid pinacol ester-->4-Iodopyrazole-->1H-Pyrazole-4-carboxaldehyde-->5-BroMo-1,2,3-triazine-->(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile-->4-bromo-1-cyclopropyl-1H-pyrazole-->1-allyl-4-bromo-1H-pyrazole-->4-Bromo-1-isopentylpyrazole-->AKOS B023947
5-[(4-BROMO-3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHYL]-1,3,4-OXADIAZOLE-2-THIOL 3-(4-BROMO-3,5-DIMETHYL-PYRAZOL-1-YLMETHYL)-BENZOIC ACID 3-BROMO-1H-PYRAZOLE 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 3-AMINO-4-BROMO-2-METHYLPYRAZOLE Pyraclostrobin 3-(4-AMINOPHENYL)-4-BROMO-1-METHYLPYRAZOLE METHYL 3-[(4-BROMO-3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHYL]BENZOATE 4-Bromopyrazole Zolpidem Pyrazole Zolpidem tartrate Bromine 2-(4-BROMO-3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETONITRILE 3-Methyl-4-bromopyrazole 4-Bromo-1-methylpyrazole Mestinon 3-AMINO-4-BROMOPYRAZOLE
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