4-Methylbenzenesulfonhydrazide

4-Methylbenzenesulfonhydrazide Basic information

Product Name:	4-Methylbenzenesulfonhydrazide
Synonyms:	n-toluolsulphonylhydrazine;p-toluenesulfohydrazide;p-tolylsulfonyl-hydrazin;4-METHYL-1-BENZENESULFONYL HYDRAZIDE;P-Benzene Sulfonyl Hydrazine;p-Toluenesulfonic acid hydrazide, p-Toluenesulfonyl hydrazide, Tosylhydrazide;Foamer TSH;p-Toluenesulfonhydrazide ,95%
CAS:	1576-35-8
MF:	C7H10N2O2S
MW:	186.23
EINECS:	216-407-3
Product Categories:	Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonyl Hydrazides;Sulfur Compounds;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;bc0001
Mol File:	1576-35-8.mol

4-Methylbenzenesulfonhydrazide Chemical Properties

Melting point	103-108 °C(lit.)
Boiling point	340.5±35.0 °C(Predicted)
density	1.42g/cm3
vapor pressure	0Pa at 20℃
refractive index	1.5400 (estimate)
Fp	60°C
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	5g/l
form	Powder
pka	9.39±0.10(Predicted)
color	White or off-white to slightly grayish
Water Solubility	5 g/L (15 ºC)
Sensitive	Moisture Sensitive
BRN	610130
Stability:	Light Sensitive
InChIKey	ICGLPKIVTVWCFT-UHFFFAOYSA-N
LogP	0.55 at 25℃
CAS DataBase Reference	1576-35-8(CAS DataBase Reference)
EPA Substance Registry System	Benzenesulfonic acid, 4-methyl-, hydrazide (1576-35-8)

Safety Information

MSDS Information

4-Methylbenzenesulfonhydrazide Usage And Synthesis

Uses	p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline.
Chemical Properties	white to off-white powder
Uses	p-Toluenesulfonyl hydrazide is used as a reagent for the preparation of tosylhydrazones. It was used to prepare dipyrazolo[1,5-a:4?,3?-c]pyridines and 1,2,3-selenadiazole derivatives.
Uses	4-Methylbenzenesulfonhydrazide was widely used reagent for the preparation of tosylhydrazones.
Flammability and Explosibility	Notclassified
Purification Methods	Dissolve the hydrazide in hot MeOH (~1g/4mL), filter through Celite and precipitate the material by adding 2-2.5 volumes of distilled H2O. Dry it in air or in a vacuum. [Fiedman et al. Org Synth Coll Vol V 1055 1973, Beilstein 11 II 66.]

4-Methylbenzenesulfonhydrazide Preparation Products And Raw materials

Raw materials	Tosyl chloride-->Hydrazine sulfate
Preparation Products	4,4'-Dimethylbiphenyl-->DI-P-TOLYLACETYLENE-->PHENYL P-TOLYL SULFONE-->1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nμ-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-methylphenyl)sulfonyl]hydrazide-->4-(Methylphenyl)sulfonylacetonitrile-->N-Cyclohexyl-4-methylbenzenesulfonamide-->P-TOLYL DISULFIDE-->BAY 11-7082-->DIHYDROEUGENOL-->1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

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