Diethyl (hydroxymethyl)phosphonate

Diethyl (hydroxymethyl)phosphonate Basic information

Product Name:	Diethyl (hydroxymethyl)phosphonate
Synonyms:	AURORA KA-1421;DIETHYL HYDROXYMETHYLPHOSPHONATE;(Hydroxymethyl)phosphonic acid, diethyl ester;(hydroxymethyl)-phosphonicacidiethylester;Phosphonic acid, (hydroxymethyl)-, diethyl ester;4-Hydroxymethyldiethylphosphonate;DIETHYL (HYDROXYMETHYL)PHOSPHONATE, TECH .;Diethyl Phosphonometanol
CAS:	3084-40-0
MF:	C5H13O4P
MW:	168.13
EINECS:	221-391-6
Product Categories:	C-C Bond Formation;Horner-Wadsworth-Emmons Reagents;Olefination
Mol File:	3084-40-0.mol

Diethyl (hydroxymethyl)phosphonate Chemical Properties

Boiling point	124-126 °C/3 mmHg (lit.)
density	1.14 g/mL at 25 °C (lit.)
refractive index	n20/D 1.444(lit.)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	13.00±0.10(Predicted)
form	Viscous Liquid
color	Clear colorless to yellow
Water Solubility	500g/L at 20℃
InChIKey	RWIGWWBLTJLKMK-UHFFFAOYSA-N
CAS DataBase Reference	3084-40-0(CAS DataBase Reference)
NIST Chemistry Reference	Diethyl hydroxymethylphosphonate(3084-40-0)
EPA Substance Registry System	Phosphonic acid, (hydroxymethyl)-, diethyl ester (3084-40-0)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	37/39-26-36-37
WGK Germany	3
TSCA	Yes
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Diethyl (hydroxymethyl)phosphonate Usage And Synthesis

Chemical Properties

Clear colorless to yellow viscous liquid

Uses

Diethyl hydroxymethylphosphonate acts as a reactant for synthesis of α And β-dialkoxyphosphoryl isothiocyanate used in antiproliferative studies, dendritic polyglycerol anions for L-selectin inhibition, phosphonates for anti-HIV-1 activity, homo and copolymers of phosphonated norbornenes, Mitsunobu reactions. It is involved in studies of FBPase inhibition by phosphonic acid-containing thaizoles.

Diethyl (hydroxymethyl)phosphonate Preparation Products And Raw materials

Raw materials	Phosphonic acid, [(acetyloxy)methyl]-, diethyl ester (9CI)-->2-Pyridinylphosphonic acid diethyl ester-->diethyl (1-hydroxy-2-Methoxyethyl)phosphonate-->Phosphonic acid, [[(4-methoxyphenyl)amino]methyl]-, diethyl ester-->ETHYL 4-(N,N-DIETHYLAMINO)BENZOATE-->1,7,13-Trioxa-4,10,16-triazacyclooctadecane-->MFCD00186556-->Diiodomethane-->Triethyl phosphite
Preparation Products	DIETHYL IODOMETHYLPHOSPHONATE-->[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid diethyl ester-->Diethyl (Ethoxymethyl)phosphonate-->Diethyl (tosyloxy)methylphosphonate

Diethyl cyanomethylphosphonate DIISOPROPYL HYDROXY(4-METHOXYPHENYL)METHYLPHOSPHONATE Diethyl phthalate DIETHYL HYDROXY(4-METHOXYPHENYL)METHYLPHOSPHONATE METHYL DIETHOXY PHOSPHINYL FORMATE DIISOPROPYL HYDROXYMETHYLPHOSPHONATE Hydroxymethyl Diethyl (hydroxymethyl)phosphonate DIETHYL (2,2,2-TRIFLUORO-1-HYDROXYETHYL)PHOSPHONATE DIETHYL(DIETHOXYMETHYL)PHOSPHONATE Diethyl methylmalonate Ethyl diethoxyphosphinylformate Diethyl ether 2-ETHOXY-TRIETHYLPHOSPHONOACETATE DIETHYL [3-(4-BROMOPHENYL)-3-CHLORO-1-HYDROXYALLYL]PHOSPHONATE Methyldiethoxyphosphine Dimethyl methylphosphonate Diethyl malonate

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Diethyl (hydroxymethyl)phosphonate

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