ChemicalBook Product Catalog Organic Chemistry Heterocyclic Compounds 4-CHLORO-2-PHENYLQUINAZOLINE

4-CHLORO-2-PHENYLQUINAZOLINE

4-CHLORO-2-PHENYLQUINAZOLINE Basic information
Product Name:4-CHLORO-2-PHENYLQUINAZOLINE
Synonyms:AKOS 93518;AM-EX-OL(R);4-CHLORO-2-PHENYLQUINAZOLINE;QUINAZOLINE, 4-CHLORO-2-PHENYL-;4-CHLORO-2-PHENYLQUINAZOLINE OR AM-ex-OL;AM-EX-OL, 97% (4-CHLORO-2-PHENYL-QUINAZO LINE);am-ex-ol tm;4-CHLORO-2-PHENYLQUINAZOLINE 97%
CAS:6484-25-9
MF:C14H9ClN2
MW:240.69
EINECS:229-346-2
Product Categories:quinazoline;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinazolines
Mol File:6484-25-9.mol
4-CHLORO-2-PHENYLQUINAZOLINE Structure
4-CHLORO-2-PHENYLQUINAZOLINE Chemical Properties
Melting point 124-126 °C(lit.)
Boiling point 383.11°C (rough estimate)
density 1.285
refractive index 1.5749 (estimate)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka0.67±0.30(Predicted)
form Crystalline Powder
color Slightly yellow to yellow
InChIKeyOBHKONRNYCDRKM-UHFFFAOYSA-N
CAS DataBase Reference6484-25-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 37/39-26
WGK Germany 3
HS Code 29339980
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
4-CHLORO-2-PHENYLQUINAZOLINE Usage And Synthesis
Chemical Propertiesslightly yellow to yellow crystalline powder
Uses4-Chloro-2-phenylquinazoline can be involved in the synthesis of biologically active molecules including: Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity.
UsesReactant involved in the synthesis of biologically active molecules including:
  • Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity
  • Quinazoline-containing piperazinylpyrimidine derivatives with antitumor activity
  • Quinazoline substituted cyclopentane as HCV NS3/4A protease inhibitors
  • Quinazolines with antibacterial and antitumor activity
  • Aurora inhibitor MK-0457

Reactant involved in Suzuki-Miyaura cross-coupling and catalyst-free / base-free water promoted nucleophilic aromatic substitution
Synthesis Reference(s)Journal of the American Chemical Society, 68, p. 1299, 1946 DOI: 10.1021/ja01211a055
4-CHLORO-2-PHENYLQUINAZOLINE Preparation Products And Raw materials
Raw materialsMethanol-->N,N-Dimethylformamide-->Phosphorus oxychloride-->Potassium carbonate-->Copper-->Benzamidine hydrochloride-->2-Bromobenzoic acid
2-(4-BROMO-PHENYL)-4-CHLORO-QUINAZOLINE CHEMBRDG-BB 5472532 4-CHLORO-2-(2-HYDROXYPHENYL)-QUINAZOLINE 4,6-DICHLORO-2-PHENYL-QUINAZOLINE AURORA 19334 QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL- AURORA 19708 6-BROMO-4-CHLORO-2-PHENYL-QUINAZOLINE 4-chloro-2-(2-chlorophenyl)quinazoline AURORA 19333 4-CHLORO-2-(4-CHLORO-PHENYL)-QUINAZOLINE 4-CHLORO-2-PHENYLQUINAZOLINE QUINAZOLINE, 4-CHLORO-7-FLUORO-2-PHENYL- 4-CHLORO-2-(3-CHLORO-PHENYL)-QUINAZOLINE AURORA 19327 4-CHLORO-2-(2-FLUORO-PHENYL)-QUINAZOLINE AURORA 19336 4-CHLORO-2-(4-METHOXY-PHENYL)-QUINAZOLINE
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