Dextromethorphan hydrobromide monohydrate

Dextromethorphan hydrobromide monohydrate Basic information

Product Name:	Dextromethorphan hydrobromide monohydrate
Synonyms:	Dextromethorphan Hydrobromide dextrorotation;dextromethorphansigmareference*standard;DMHM;(9α,13α,14α)-3-Methoxy-17-MethylMorphinan HydrobroMide Hydrate;3-Methoxy-17-Methyl-9α,13α,14α-Morphinan HydrobroMide Hydrate;d-3-Methoxy-N-MethylMorphinan HydrobroMide Monohydrate;DextroMethorphan hydrobroMide:Monohydrat;DextroMethorphan hydrobroMide hydrate
CAS:	6700-34-1
MF:	C18H28BrNO2
MW:	370.33
EINECS:	629-741-3
Product Categories:	Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Other APIs
Mol File:	6700-34-1.mol

Dextromethorphan hydrobromide monohydrate Chemical Properties

Melting point	116-119°C
alpha	[α]D25 +26～+30° (c=1.85, H2O)
Fp	11 °C
storage temp.	Store at RT
solubility	Sparingly soluble in water, freely soluble in ethanol (96 per cent).
form	solid
color	White to Off-White
PH	pH (10g/l, 25℃) : 5.2～6.5
BRN	6453793
InChIKey	QYPSYPPSHXDFLV-UHFFFAOYSA-N
LogP	1.351 (est)
CAS DataBase Reference	6700-34-1(CAS DataBase Reference)

Safety Information

MSDS Information

Dextromethorphan hydrobromide monohydrate Usage And Synthesis

Description	Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC₅₀ = 0.55 μM) and nicotinic receptors (IC₅₀s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC₅₀ = 60 μM) and voltage-gated sodium channels (IC₅₀ = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.
Chemical Properties	White Solid
Uses	An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).
Uses	Antitussive;Opioid ligand
Definition	ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan.
Brand name	Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).
Biological Activity	Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.

Dextromethorphan hydrobromide monohydrate Preparation Products And Raw materials

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