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| | cannabisin F Basic information |
| Product Name: | cannabisin F | | Synonyms: | cannabisin F;2-Propenamide, 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)- | | CAS: | 163136-19-4 | | MF: | C36H36N2O8 | | MW: | 624.68 | | EINECS: | | | Product Categories: | | | Mol File: | 163136-19-4.mol |  |
| | cannabisin F Chemical Properties |
| Boiling point | 961.0±65.0 °C(Predicted) | | density | 1.295±0.06 g/cm3(Predicted) | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 9.78±0.31(Predicted) |
| | cannabisin F Usage And Synthesis |
| Biological Activity | Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2[1].
Cannabisin F (0~15 μM; 1 hour; BV2 microglia cells) inhibits the phosphorylation of IκBα, p65, but enhances the expression of Nrf2 and HO-1[1].Cannabisin F (0~15 μM; 24 hours; BV2 microglia cells) has no significant effect on cell survival, inhibits IL-6 and TNF-α production and their mRNA expression, inhibits the production of ROS and increases the expression of SIRT1[1]. | | target | Immunology & Inflammation related | | References | [1]. Wang S, et al. Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator. Int J Mol Sci. 2019;20(3):507. Published 2019 Jan 25. |
| | cannabisin F Preparation Products And Raw materials |
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