2,5-PYRIDINEDICARBOXYLIC ACID

2,5-PYRIDINEDICARBOXYLIC ACID Basic information
Product Name:2,5-PYRIDINEDICARBOXYLIC ACID
Synonyms:pyridine2,5-dicarboxylate;2,5-LUTIDINIC ACID;2,5-PYRIDINECARBOXYLIC ACID;2,5-PYRIDINEDICARBOXYLIC ACID;ISOCINCHOMERIC ACID;ISOCINCHOMERONIC ACID;RARECHEM AL BO 2394;PYRIDINE-2,5-DICARBOXYLIC ACID
CAS:100-26-5
MF:C7H5NO4
MW:167.12
EINECS:202-834-2
Product Categories:Heterocycle-Pyridine series;Aromatics;Pyridines, Pyrimidines, Purines and Pteredines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds
Mol File:100-26-5.mol
2,5-PYRIDINEDICARBOXYLIC ACID Structure
2,5-PYRIDINEDICARBOXYLIC ACID Chemical Properties
Melting point 242-247 °C (dec.)(lit.)
Boiling point 295.67°C (rough estimate)
density 1.5216 (rough estimate)
refractive index 1.6280 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility 1.2g/l
pka3.06±0.10(Predicted)
form Fine Crystalline Powder
color Yellow to green
Water Solubility 1.237g/L(25 ºC)
Merck 14,5159
BRN 131697
InChIKeyLVPMIMZXDYBCDF-UHFFFAOYSA-N
CAS DataBase Reference100-26-5(CAS DataBase Reference)
EPA Substance Registry System2,5-Pyridinedicarboxylic acid (100-26-5)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
HS Code 29333990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
2,5-PYRIDINEDICARBOXYLIC ACID Usage And Synthesis
Chemical Propertiesyellow to green fine crystalline powder
UsesUsed in the preparation of new 2,5-pyridinedicarboxylic acids derivatives as antiviral agents.
Uses2,5-Pyridinedicarboxylic acid can be used:
  • In the synthesis of diorganotin(IV) 2,5-pyridinedicarboxylates.
  • In the preparation of three-dimensional coordination polymers of lanthanide 2,5-pyridinedicarboxylates by hydrothermal method.
  • As an organocatalyst in the synthesis of 1,5-benzodiazepine derivatives via one pot three-component reaction.

DefinitionChEBI: A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 5.
Purification MethodsCrystallise it from H2O or dilute HCl. [Napoli J Inorg Nucl Chem 32 1907 1970, Beilstein 22 H 153, 22 I 533, 22 II 105, 22 III/IV 1632, 22/4 V 124.]
2,5-PYRIDINEDICARBOXYLIC ACID Preparation Products And Raw materials
Preparation ProductsSODIUM NICOTINATE-->Methyl 6-(hydroxymethyl)nicotinate-->Pyridine-2,5-dicarbaldehyde-->2,5-PYRIDINEDICARBOXYLIC ACID DI-N-PROPYL ESTER-->METHYL 6-FORMYLNICOTINATE-->Nicotinic acid
Lercanidipine hydrochloride 1,3(2H)-PYRIDINEDICARBOXYLIC ACID, 3-METHYL 1-PHENYL ESTER,1,3(2H)-PYRIDINEDICARBOXYLIC ACID, 3-METHYL 1-PHENYL ESTER 2,5-PYRIDINEDICARBOXYLIC ACID DI-N-PROPYL ESTER 5-(ETHOXYCARBONYL)-6-METHYLPYRIDINE-2-CARBOXYLIC ACID 2,5-PYRIDINEDICARBOXYLIC ACID, 6-METHYL-, 2,5-DIETHYL ESTER Pyridine-2,6-dicarboxylic acid DIMETHYL PYRIDINE-2,5-DICARBOXYLATE 6-(Ethoxycarbonyl)nicotinic acid 6-METHYL-2,3-PYRIDINEDICARBOXYLIC ACID 4-PHENYL-2,5-PYRIDINEDICARBOXYLIC ACID DIMETHYL 3-AMINOPYRIDINE-2,5-DICARBOXYLATE AKOS 220-61 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE 2,5-PYRIDINEDICARBOXYLIC ACID 5-(Methoxycarbonyl)pyridine-2-carboxylic acid barnidipine 2,5-PYRIDINEDICARBONYL ACID-13C7

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