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AMIPROFOS METHYL

AMIPROFOS METHYL Basic information
Product Name:AMIPROFOS METHYL
Synonyms:amiprophosmethyl;bayntn6867;bayntn80;n-isopropyl-phosphoramidothioicacio-methylo-(2-nitro-p-tolyl)ester;ntn6867;O-METHYL O-(2-NITRO-P-TOLYL) N-ISOPROPYL-PHOSPHORAMIDOTHIONATE;AMIPROFOS METHYL;ntn80
CAS:36001-88-4
MF:C11H17N2O4PS
MW:304.3
EINECS:252-829-4
Product Categories:
Mol File:36001-88-4.mol
AMIPROFOS METHYL Structure
AMIPROFOS METHYL Chemical Properties
Melting point ~65 °C
Boiling point 146.6°C
density 1.275±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka-0.73±0.70(Predicted)
color White to Off-White
BRN 2000833
EPA Substance Registry SystemAmiprofos-methyl (36001-88-4)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS TB5100000
ToxicityLD50 orl-rat: 309 mg/kg 85AREA 2,212,77
MSDS Information
ProviderLanguage
SigmaAldrich English
AMIPROFOS METHYL Usage And Synthesis
DescriptionAmiprofos-methyl (APM) is a phosphoric amide herbicide. It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel in a dose-dependent manner. APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM. The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM. APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.
UsesAmiprofos-methyl is useful in herbicide compositions.
Biochem/physiol ActionsHerbicide that prevents microtubule polymerization in plant cells, but not animal cells. Crop plants resistant to amiprofos-methyl and several other herbicides have been developed by insertion of a xenobiotic-detoxifying human gene CYP2B6.
Safety ProfileA poison by ingestion. Lowtoxicity by skin contact. When heated to decomposition itemits toxic vapors of NOx, SOx, and POx.
AMIPROFOS METHYL Preparation Products And Raw materials
Raw materialsIsopropylamine-->Basic Orange 2-->O-methyl dichlorothiophosphate-->2-Nitro-p-cresol
Pyriproxyfen Paraquat water AMIPROPHOS AMIPROFOS METHYL O,O-Dimethyl phosphoramidothioate
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