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| | Landiolol hydrochloride Basic information |
| Product Name: | Landiolol hydrochloride | | Synonyms: | [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride;Landiolol hydrochloride;Benzenepropanoic acid, 4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester, (S-(R*,R*))-, hydrochloride;Ono 1101 hydrochloride;-2,2-Dimethyl-1,3-dioxolan-4-yl);-2-hydroxy-3-((2-(morpholine-4-carboxamido);methyl 3-(4-((S);propanoate hydrochloride | | CAS: | 144481-98-1 | | MF: | C25H40ClN3O8 | | MW: | 546.06 | | EINECS: | 1308068-626-2 | | Product Categories: | APIs;API;144481-98-1 | | Mol File: | 144481-98-1.mol |  |
| | Landiolol hydrochloride Chemical Properties |
| Melting point | 125.4° | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) | | form | Solid | | color | White to Off-White |
| RTECS | DA8346700 | | HS Code | 2934.99.4700 | | Toxicity | LD50 in mice (mg/kg): 290 i.v. (Iguchi) |
| | Landiolol hydrochloride Usage And Synthesis |
| Description | Landiolol hydrochloride (14) was launched in Japan by
Ono for the treatment of intraoperative tachyarrhythmia. It
improves tachyarrhythmia by selectively blocking β1
receptors located mainly in the heart and by inhibiting the
action of catecholamine. | | Uses | Landiolol is an ultra-short acting beta blocker that is used to treat patients with cardiac arrhythmias and is also used to treat tachycardia during anasthesia. | | Definition | ChEBI: Landiolol hydrochloride is a member of morpholines. | | Synthesis | The synthesis of landiolol
appeared in an earlier patent in 1990. Esterification of 3-
(4-hydroxyphenyl)propionic acid (141) with 2,2-dimethyl-
1,3-dioxolan-4-ylmethyl chloride (142) in DMSO gave
desired ester 143 in 57% yield. Treatment of phenol 143
with bromo epoxide 144 in the present of K2CO3 afforded
ether 145 in 76% yield. Epoxide 145 was then reacted with
free amine 146 via a neucleophilic ring opening process to
provide landiolol (14). 
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| | Landiolol hydrochloride Preparation Products And Raw materials |
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