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| | Silibinin Basic information |
| | Silibinin Chemical Properties |
| Melting point | 164-174°C | | alpha | D20 +11° (c = 0.25 in acetone + alcohol) | | Boiling point | 793.0±60.0 °C(Predicted) | | density | 1.527±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Acetone (Sparingly), DMSO, Methano (Sparingly) | | form | Solid | | pka | pKa 6.42±0.04 (Uncertain) | | color | Pale Yellow | | Water Solubility | 54mg/L(24.99 ºC) | | Merck | 13,8607 | | Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. | | LogP | 4.232 (est) | | CAS DataBase Reference | 22888-70-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-24/25-22-36 | | RIDADR | 3172 | | WGK Germany | 3 | | RTECS | DJ2981770 | | HS Code | 29329990 | | Toxicity | LD50 intravenous in mouse: 1056mg/kg |
| | Silibinin Usage And Synthesis |
| Chemical Properties | solid | | Originator | Legalon,Madaus,W. Germany,1969 | | Uses | Silibinin has been used:
- to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR)
- to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay
- to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing
- to study its inhibitory effect on Escherichia coli ATP synthase
| | Uses | Labelled Silybin (S465850). Hepatoprotectant. | | Definition | ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. | | Manufacturing Process | Silymarin comprising polyhydroxyphenyl chromanones is recovered from the
dried fruit of Silybum marianum Gaertn. by separating the fatty oils
therefrom, extracting the remaining solid residue with ethyl acetate,
evaporating the ethyl acetate and dissolving the dry residue in a solvent
mixture comprising methanol, water and petroleum ether to form a two-phase
system wherein the chromanones are contained in the lower phase,
recovering the polyhydroxyphenyl chromanones from the lower phase after
subjecting same to multiple counter-current contact with petroleum ether. | | Therapeutic Function | Hepatoprotectant | | General Description | Silibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L). | | Biochem/physiol Actions | Silibinin functions as a hepatoprotectant in patients with acute and chronic liver injury. This flavonoid fights against various cancer cells including, prostate, skin, breast, colon, lung, bladder and hepatocellular carcinoma (HCC). Silibinin exhibits its efficacy as an anti-cancer agent by blocking the secretion of proangiogenic factors from tumor cells, and by hindering growth and inducing apoptotic death of endothelial cells. In addition, it also interrupts capillary tube formation on Matrigel. Silibinin might be a good candidate for chemoprevention of prostate cancer (PC). It might be used as a potential therapeutic regimen for the treatment of endometriosis in vitro and in vivo. |
| | Silibinin Preparation Products And Raw materials |
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