BROMOBIS(PH3P)(N-SUCCINIMIDE)PD(II) Chemical Properties
Melting point
223-228 °C (dec.) (lit.)
Safety Information
WGK Germany
3
MSDS Information
BROMOBIS(PH3P)(N-SUCCINIMIDE)PD(II) Usage And Synthesis
Uses
trans-Bromo(N-succinimidyl)bis(triphenylphosphine)palladium(II) may be used in the following processes:
As a catalyst for the preparation of 6-cyano-2-(3-fluoro-benzyl)-indole-1-carboxylic acid tert-butyl ester via Suzuki cross-coupling reaction between 1-boc-6-cyanoindole-2-boronic acid and 3-fluorobenzyl bromide. This method does not involve the use of strong bases or toxic reagents and also the use of this catalyst minimizes protodeboronation.
As a precatalyst for the Suzuki-Miyaura cross-coupling reaction between alkenyl tosylates and alkenyl MIDA boronates in the absence of phosphine ligands. For less activated alkenyl tosylate, the addition of tricyclohexylphosphine tetrafluoroborate improves the reactivity.
BROMOBIS(PH3P)(N-SUCCINIMIDE)PD(II) Preparation Products And Raw materials
