|
| | 8,8'-DIAPOCAROTENEDIOIC ACID Basic information |
| Product Name: | 8,8'-DIAPOCAROTENEDIOIC ACID | | Synonyms: | CROCETIN;CROCETIN, TRANS-;8,8'-DIAPOCAROTENEDIOIC ACID;2,6,11,15-TETRAMETHYLHEXADECA-2,4,6,8,10,12,14-HEPTAENEDOIC ACID;TRANS-CROCETIN;8,8'-diapo-psi,psi-carotenedioic acid;Alpha-Crocetin;roceic acid | | CAS: | 27876-94-4 | | MF: | C20H24O4 | | MW: | 328.4 | | EINECS: | 248-708-0 | | Product Categories: | Carotenoids | | Mol File: | 27876-94-4.mol |  |
| | 8,8'-DIAPOCAROTENEDIOIC ACID Chemical Properties |
| Melting point | 285° | | Boiling point | 386.14°C (rough estimate) | | density | 1.0786 (rough estimate) | | FEMA | 2998 | SAFFRON (CROCUS SATIVUS L.) | | refractive index | 1.4434 (estimate) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Slightly, Heated), Methanol (Slightly) | | form | Solid | | pka | 4.39±0.19(Predicted) | | color | Red to Very Dark Red | | Stability: | Light Sensitive | | LogP | 4.312 (est) |
| | 8,8'-DIAPOCAROTENEDIOIC ACID Usage And Synthesis |
| Chemical Properties | Red, rhomboid crystals.Soluble in pyridine and dilute sodium hydroxide;
slightly soluble in water and organic solvents. Combustible. | | Uses | Experimental treatment of arteriosclerosis by
increasing oxygen diffusion through arterial walls,
thus decreasing buildup of cholesterol. | | Uses | Crocetin is a carotenoid derived from saffron, and is shown to have anticancer effects in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. | | Definition | ChEBI: A 20-carbon dicarboxylic acid which is a diterpenoid and natural carotenoid. Found in the crocus flower, it has been administered as an anti-fatigue dietary supplement. | | Anticancer Research | It is a natural apocarotenoid dicarboxylic acid obtained from saffron, and saffron isa spice from the flower of the Saffron crocus and present in the dry stigmas of theplant Crocus sativus which can be used as a food colorant. It is reported to be anovel anticancer agent against hepatocellular carcinoma, pancreatic cancer, lungcancer, skin carcinoma, breast cancer, and colorectal cancer. It inhibits the nucleicacid synthesis, enhances antioxidant system, induces apoptosis, hinders growthfactor signaling pathways, and thus affects the growth of cancer cells. It showseffects in the reduction of LPS-induced nitric oxide release; in the reduction ofproduced IL-1β, TNF-α, and intracellular ROS; in the activation of NF-κB; and inthe blockade of LPS (Wang et al. 2012; Gutheil et al. 2012). | | target | COX | NO |
| | 8,8'-DIAPOCAROTENEDIOIC ACID Preparation Products And Raw materials |
|
