ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Carboxylic acid derivatives 1H-Imidazole-4-carboxylic acid

1H-Imidazole-4-carboxylic acid

1H-Imidazole-4-carboxylic acid Basic information
Product Name:1H-Imidazole-4-carboxylic acid
Synonyms:4-hydroxy imizodale;Imidazol-4-carboxylic acid;1H-Imidazole-5-carboxylic acid 98%;4-IMIDAZOLECARBOXYLIC ACID 98;1H-Imidazole-4-carboxylic acid,98%;3H-Imidazole-4-carboxylic acid, 5-Carboxy-1H-imidazole, 1H-Imidazole-4-carboxylic acid, 4-Carboxy-1H-imidazole;1H-IMidazole-4;1H- iMidazole-4- forMic acid
CAS:1072-84-0
MF:C4H4N2O2
MW:112.09
EINECS:214-017-8
Product Categories:Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;pharmacetical;blocks;Carboxes;Imidazoles;Carboxylic Acids;Heterocyclic Compounds;Heterocycle;Imidaxoles;Imidazoles & Benzimidazoles;Building Blocks;Heterocyclic Building Blocks
Mol File:1072-84-0.mol
1H-Imidazole-4-carboxylic acid Structure
1H-Imidazole-4-carboxylic acid Chemical Properties
Melting point 294-295 °C (lit.)
Boiling point 495.0±18.0 °C(Predicted)
density 1.524±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (sparingly)
pka2.69±0.10(Predicted)
form Liquid
color Clear colorless
InChIKeyNKWCGTOZTHZDHB-UHFFFAOYSA-N
CAS DataBase Reference1072-84-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS NI4001000
HazardClass IRRITANT
HS Code 29332900
MSDS Information
ProviderLanguage
SigmaAldrich English
1H-Imidazole-4-carboxylic acid Usage And Synthesis
Chemical PropertiesGray or tan powder
Uses4-Imidazolecarboxylic acid (ICA) was used in the synthesis of triphenymethyl-protected 4-imidazole carboxylic acid (trityl-ImCOOH) which is employed to functionalize poly(propylene imine) dendrimers.
It may be used in the following studies:
  • In the synthesis of lanthanide sulfate–carboxylates, [Ln(HIMC)(SO4)(H2O)] (Ln = Dy and Eu, HIMC = 4-imidazolecarboxylic acid) by in situ decarboxylation in the presence of Cu(II) ions.
  • As an internal standard to obtain calibration curve by plotting the peak area ratios of histamine (HA) and several metabolites isolated from C3H/HeNCrj mice hair relative to ICA.
  • In the synthesis of tetranuclear manganese carboxylate complexes possessing imidazole-based N/O chelating ligands.
General Description4-Imidazolecarboxylic acid (1H-imidazole-4-carboxylic acid, H2imc) is an imidazole derivative that contains an imidazole group and a carboxylate group. It has been widely utilized to generate different types of coordination polymers. The anion of 4-imidazolecarboxylic acid has been reported to stabilize binuclear hydroxo complexes of trivalent lanthanides in the pH range 7-10.
1H-Imidazole-4-carboxylic acid Preparation Products And Raw materials
Raw materialsSulfuric acid-->Acetic anhydride-->Triethyl orthoformate-->Anisole-->4,5-Imidazoledicarboxylic acid-->Diaminomaleonitrile
Preparation Products1-Trityl-1H-imidazole-4-carboxylic acid-->Imidazole-4-methanol
2,7-DIMETHYLPYRIDO[1,6-A]-1H-IMIDAZOLE-3-CARBOXYLIC ACID, ETHYL ESTER Calcium formate Ethyl imidazole-4-carboxylate RO 15-4513 Retinoic acid Levamisole 4-Aminobenzoic acid 4-ETHOXYCARBONYLIMIDAZOLE-2-THIOL 2,7-DIMETHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID 1H-Imidazole-4-carboxylic acid Imidazole Chromium picolinate ETHYL 1-(4-CHLOROBENZYL)-5-METHYLIMIDAZOLE-4-CARBOXYLATE CARBOXYLIC ACID ETHYL 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLATE Benzoic acid Bis(2-ethylhexyl) phthalate Methyl formate
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