ChemicalBook Product Catalog Chemical Reagents Organic reagents Amide 2-METHYLACETANILIDE

2-METHYLACETANILIDE

2-METHYLACETANILIDE Basic information
Product Name:2-METHYLACETANILIDE
Synonyms:Acetamide,N-(2-methylphenyl)-;Acet-o-toluidide;N-Acetyl-o-toluidine 2'-Methylacetanilide;Prilocaine Impurity 16;2-Methylacetaniline;o-Acetotoluidine;n-(2-methylphenyl)-acetamid;N-(2-Methylphenyl)acetamide
CAS:120-66-1
MF:C9H11NO
MW:149.19
EINECS:204-414-4
Product Categories:Anilines, Amides & Amines
Mol File:120-66-1.mol
2-METHYLACETANILIDE Structure
2-METHYLACETANILIDE Chemical Properties
Melting point 109-112 °C
Boiling point 296 °C
density 1.16
refractive index 1.5279 (estimate)
Fp 296°C
storage temp. Sealed in dry,Room Temperature
solubility It is slightly soluble in acetone, chloroform, toluene, benzene.
pka15.13±0.70(Predicted)
form Solid
color Needles
Merck 14,74
BRN 2207054
CAS DataBase Reference120-66-1(CAS DataBase Reference)
EPA Substance Registry Systemo-Acetotoluidide (120-66-1)
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-22
Safety Statements 37/39-26-36-36/37
RTECS AN2900000
Hazard Note Harmful
TSCA Yes
HS Code 29242990
Hazardous Substances Data120-66-1(Hazardous Substances Data)
Toxicitymma-sat 1 mg/plate NTPTB* JAN 82
MSDS Information
ProviderLanguage
ACROS English
ALFA English
2-METHYLACETANILIDE Usage And Synthesis
Chemical PropertiesWHITE TO OFF-WHITE CRYSTALLINE POWDER
Useso-Methylacetanilide is a substituted acetanilide that is used as precursor for various pharmaceuticals including their intermediates.
UsesAcetanilide is used as an inhibitor of peroxides and?stabilizer for cellulose ester varnishes.?It is used as an intermediate for the synthesis of?rubber accelerators, dyes and dye intermediate and camphor. It is used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates.
DefinitionChEBI: 2`-Methylacetanilide is a member of toluenes.
Synthesis Reference(s)Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Organic Syntheses, Coll. Vol. 5, p. 650, 1973
General DescriptionColorless crystals. Insoluble in water.
Air & Water ReactionsWater insoluble.
Reactivity Profile2-METHYLACETANILIDE is an amide. Amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health HazardACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products.
Safety ProfileModerately toxic by ingestion.Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Purification MethodsCrystallise the toluidide from hot H2O (solubility 1g/210mL), EtOH or aqueous EtOH. UV: max 230 and 280nm (EtOH). [Beilstein 12 H 792, 12 I 376, 12 II 439, 12 III 1853, 12 IV 1755.]
2-Chloro-N-(2,6-dimethylphenyl)acetamide STRYCHNINE 10,11-Dimethoxystrychnine 2',6'-DIMETHYLACETANILIDE N-(2-ETHYLPHENYL)-3-HYDROXY-2-NAPHTHALENECARBOXAMIDE N-(4-AMINO-2-METHYLPHENYL)-4-CHLOROPHTHALIMIDE 6(5H)-Phenanthridone 5,6,11,12-TETRAHYDRODIBENZ[B,F]AZOCIN-6-ONE N N'-BIS(2 5-DI-T-BU-PHENYL)-3 4 9 10- LABOTEST-BB LT00012623 N-Acetylanthranilic acid TRYPTANTHRIN 2'-Methylacetoacetanilide AZOIC DIAZO COMPONENT 41 6-BROMO-4-METHYL-1-PHENYLANTHRAPYRIDONE 2-CHLORO-4-BENZAMIDO-5-METHYLBENZENE DIA XYLIDYL BLUE I SODIUM SALT 4-ACETAMIDO-9-FLUORENONE
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