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| Product Name: | AG 99 | | Synonyms: | TYRPHOSTIN AG 99;TYRPHOSTIN B40;TYRPHOSTIN 46;TYRPHOSTIN A46;3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE;AG 99;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide | | CAS: | 122520-85-8 | | MF: | C10H8N2O3 | | MW: | 204.18 | | EINECS: | | | Product Categories: | ALCOHOL;Intracellular Signaling | | Mol File: | 122520-85-8.mol |  |
| | AG 99 Chemical Properties |
| Melting point | 247 °C | | Boiling point | 544.4±50.0 °C(Predicted) | | density | 1.482±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO | | form | Brown solid. | | pka | 8.81±0.10(Predicted) |
| | AG 99 Usage And Synthesis |
| Uses | Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation. | | Biological Activity | Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro . | | references | [1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633. |
| | AG 99 Preparation Products And Raw materials |
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