|
| | TELMISARTAN-D3 Basic information |
| | TELMISARTAN-D3 Chemical Properties |
| Melting point | 262-265°C | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | form | Solid | | color | White to Beige |
| | TELMISARTAN-D3 Usage And Synthesis |
| Description | Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (; EC50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis. | | Chemical Properties | Off-White Crystalline Solid | | Uses | Labelled Telmisartan, an angiotensin II receptor antagonist | | Uses | TelMisartan-d3 is an angiotensin II receptor antagonist.
| | Uses | TelMisartan-d3 can be intended for use as an internal standard for the quantification of Telmisartan by GC- or LC-mass spectrometry.
|
| | TELMISARTAN-D3 Preparation Products And Raw materials |
|
