Choline salicylate

Choline salicylate Basic information
Product Name:Choline salicylate
Synonyms:Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 2-hydroxybenzoic acid (1:1);BASIONIC(R) FS 65, COL Salicylat;salicol;salicylicacid,ion(1-),choline;salicylicacidcholinesalt;satibon;COL SALICYLAT;COL SALICYLATE
CAS:2016-36-6
MF:C12H19NO4
MW:241.28
EINECS:217-948-8
Product Categories:
Mol File:2016-36-6.mol
Choline salicylate Structure
Choline salicylate Chemical Properties
Melting point 49.5-50.0°
Boiling point 384.06°C (rough estimate)
density 1.1442 (rough estimate)
refractive index 1.4596 (estimate)
Fp 183 °C
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Colourless to Light Brown Oil
Stability:Hygroscopic
EPA Substance Registry SystemEthanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 2-hydroxybenzoic acid (1:1) (2016-36-6)
Safety Information
WGK Germany 2
RTECS GA6475000
3-10
MSDS Information
ProviderLanguage
SigmaAldrich English
Choline salicylate Usage And Synthesis
DescriptionCholine salicylate is absorbed more rapidly than aspirin and produces higher salicylate plasma levels. It is available as a mint-flavored liquid.
OriginatorArthropan ,Purdue , US,1959
UsesCholine Salicylate displays protective effects in the treatment of Alzheimer’s disease. It has the potential to relieve pain associated with mouth ulcers.
DefinitionChEBI: Choline salicylate is a hydroxybenzoic acid. It is functionally related to a salicylic acid.
Manufacturing ProcessA method of preparation is to react an acid salt of choline (such as choline chloride or choline bromide) with an alkaline salt of salicylic acid (such as sodium salicylate, potassium salicylate, or magnesium salicylate) in an alcoholic media.
Brand nameArthropan (Purdue Frederick).
Therapeutic FunctionAnalgesic; Antipyretic
Clinical UseCholine salicylate has a lower incidence of GI side effects compared with aspirin, and it has been shown to be particularly useful in treating juvenile rheumatoid arthritis, in which aspirin was ineffective.
Choline salicylate Preparation Products And Raw materials
Raw materialsCholine chloride-->Sodium salicylate-->Choline hydroxide-->Salicylic acid
Sodium salicylate Salicylic acid Tetraethylammonium bromide Choline hydroxide Methyl 2-hydroxyethyl cellulose Tetraethylammonium hydroxide 2-(2-Aminoethylamino)ethanol Acetylsalicylic acid AMMONIUM SALICYLATE Choline salicylate 5-Sulfosalicylic acid dihydrate Choline chloride Hydroxyethyl Cellulose Hydroxyethyl starch 2-(METHYLSULFONYL)ETHANOL ALLOPHYCOCYANIN Sodium isethionate Methyl salicylate

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