4-Fluorobenzylamine

4-Fluorobenzylamine Basic information
Product Name:4-Fluorobenzylamine
Synonyms:4-Fluorobenzylamine ,99%;4-FluorobenzylaMine, 97% 25GR;p-FluorobenzeneMethanaMine;4-FLUOROBENZYLAMINE FOR SYNTHESIS;4-FluorobenzylaMine0.99;(4-Fluorophenyl)methanamine;4-fluoro-benzenemethanamin;Benzylamine, p-fluoro-
CAS:140-75-0
MF:C7H8FN
MW:125.14
EINECS:205-430-4
Product Categories:Anilines, Aromatic Amines and Nitro Compounds;Amines;Amine;Aromatics;C7;Nitrogen Compounds;fine chemicals;bc0001
Mol File:140-75-0.mol
4-Fluorobenzylamine Structure
4-Fluorobenzylamine Chemical Properties
Melting point 183 °C
Boiling point 183 °C (lit.)
density 1.095 g/mL at 25 °C (lit.)
refractive index n20/D 1.512(lit.)
Fp 152 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
pka9.01±0.10(Predicted)
form Liquid
color Clear colorless to light yellow
Specific Gravity1.101.095
Water Solubility Soluble in water.
Sensitive Air Sensitive
BRN 636501
InChIKeyIIFVWLUQBAIPMJ-UHFFFAOYSA-N
CAS DataBase Reference140-75-0(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenemethanamine, 4-fluoro-(140-75-0)
EPA Substance Registry SystemBenzenemethanamine, 4-fluoro- (140-75-0)
Safety Information
Hazard Codes C,Xi
Risk Statements 34-20/21/22
Safety Statements 26-27-36/37/39-45-36/39
RIDADR UN 2735 8/PG 2
WGK Germany 3
10-34
Hazard Note Irritant
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29214980
MSDS Information
ProviderLanguage
4-Fluorobenzylamine English
ACROS English
SigmaAldrich English
ALFA English
4-Fluorobenzylamine Usage And Synthesis
Chemical PropertiesColorless to light yellow liquid.
Uses4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.
General Description[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.
SynthesisIn a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%.
4-Fluorobenzoic acid 4-Fluorobenzamide 2-CHLORO-4-FLUOROBENZAMIDE Ethyl nicotinate Trimethoprim 2,4-DIFLUOROBENZAMIDE Methylamine Benzylamine Dibenzylamine 4-Fluorobenzylamine 3,4-Difluorobenzylamine 4-FLUORO BENZYLAMINE HYDROCHLORIDE Trimethylamine Meglumine Methylamine hydrochloride EXO1 Phenoxybenzamine hydrochloride N-Methylbenzylamine

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.