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| | Manidipine hydrochloride Basic information |
| Product Name: | Manidipine hydrochloride | | Synonyms: | 4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride;cv-4093dihydrochlorde;franidipinehydrochloride;MANIDIPINE DIHYDROCHLORIDE;MANIDIPINE HYDROCHLORIDE;1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI);Calslot | | CAS: | 89226-75-5 | | MF: | C35H40Cl2N4O6 | | MW: | 683.62 | | EINECS: | 680-304-3 | | Product Categories: | Antihypertensive;API | | Mol File: | 89226-75-5.mol |  |
| | Manidipine hydrochloride Chemical Properties |
| Melting point | 157-163°; mp 174-180°; mp 167-170° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | color | White | | Water Solubility | Soluble in DMSO. Slightly soluble in water and ethanol
/n | | Merck | 14,5743 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | CAS DataBase Reference | 89226-75-5(CAS DataBase Reference) |
| RIDADR | UN 2811 6.1/PG III | | RTECS | US7975300 | | HS Code | 2933.59.8000 | | HazardClass | 6.1 | | PackingGroup | III | | Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba) |
| | Manidipine hydrochloride Usage And Synthesis |
| Description | Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4 | | Uses | aldosterone antagonist | | Uses | Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. | | Definition | ChEBI: Manidipine dihydrochloride is a diarylmethane. | | References | Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223
McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923
Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526
Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130 |
| | Manidipine hydrochloride Preparation Products And Raw materials |
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