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| | 2-Methylpropanedioic acid Basic information |
| | 2-Methylpropanedioic acid Chemical Properties |
| Melting point | 128-130 °C (lit.) | | Boiling point | 272.71°C (rough estimate) | | density | 1.45 | | refractive index | 1.4304 (estimate) | | Fp | 2℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 3.07, 5.76(at 25℃) | | form | Crystalline Powder | | color | White | | Specific Gravity | 1.455 | | PH | 3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution) | | Water Solubility | soluble | | BRN | 1756084 | | CAS DataBase Reference | 516-05-2(CAS DataBase Reference) | | NIST Chemistry Reference | Methylmalonic acid(516-05-2) |
| | 2-Methylpropanedioic acid Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | 2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
| | Uses | Methylmalonic acid can be used as a substrate in:
- Esterification reactions by various catalysts.
- Synthesis of pyrimidinium betaines with formamidine.
- Synthesis of malonic acid half thioester (MAHT).
| | Definition | ChEBI: A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. | | Biological Functions | Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease. | | General Description | Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS. | | storage | Store at RT | | Purification Methods | The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.] |
| | 2-Methylpropanedioic acid Preparation Products And Raw materials |
| Raw materials | 1,3-Di-tert-butyl2-methylpropanedioate-->3-ethoxy-2-Methyl-3-oxopropanoic acid-->Propanoic acid, 2-cyano--->Dimethyl methylmalonate-->DIETHYL MERCURY-->4-METHYL-PYRIDINE-2-CARBOXYLIC ACID-->Diethyl methylmalonate-->2-Chloropropionic acid | | Preparation Products | cyclamen aldehyde-->5-hydroxy-3-Methyl-2(5H)-furanone-->2-Propenoic acid, 3-(2,6-dichlorophenyl)-2-methyl--->Benzenepropanoic acid, β-amino-α-methyl-, (αR,βS)-rel--->2H-Pyrano[3,2-c]pyridine-2,5(6H)-dione, 4-hydroxy-3,6,7-trimethyl- (9CI) |
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