Boc-6-AMinocaproic acid

Boc-6-AMinocaproic acid Basic information
Product Name:Boc-6-AMinocaproic acid
Synonyms:Boc-6-Ahx-OH ,98.5%(HPLC);Boc-6-Ahx-OH,6-(Boc-amino)caproic acid, 6-(Boc-amino)hexanoic acid, Boc-6-aminohexanoic acid;Boc-6-Ahx-OH(Boc-6-aMinohexanoic acid);Boc-ε- AMinocaproic acid Boc-ε- AMinocaproic acid;6-[N-(tert-Butoxycarbonyl)aMino]caproic Acid;N-(tert-Butoxycarbonyl)-ε-aMinocaproic Acid;N-(tert-Butoxycarbonyl)-ε-aMinohexanoic Acid;N-(tert-Butyloxycarbonyl)-ε-aMinocaproic Acid
CAS:6404-29-1
MF:C11H21NO4
MW:231.29
EINECS:
Product Categories:Amino Acid Derivatives;Aliphatics;Amino Acids;Unusual Amino Acids;Amines
Mol File:6404-29-1.mol
Boc-6-AMinocaproic acid Structure
Boc-6-AMinocaproic acid Chemical Properties
Melting point 35-40 °C
Boiling point 166°C/0.3mmHg(lit.)
density 1.065±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate
pka4.76±0.10(Predicted)
form Powder
color White
Water Solubility Soluble in chloroform and ethyl acetate. Slightly soluble in water.
BRN 2049561
CAS DataBase Reference6404-29-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-26
WGK Germany 3
21
HazardClass IRRITANT
HS Code 29241990
MSDS Information
ProviderLanguage
SigmaAldrich English
Boc-6-AMinocaproic acid Usage And Synthesis
DescriptionBoc-6-aminohexanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical PropertiesColorless crystal
Uses6-(Boc-amino)hexanoic acid is used in the preparation of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator.
UsesProtected ε-Aminocaproic Acid (A603015), Boc-6-AMinocaproic acid can be used in the preparatiom of esters of 6-aminohexanoic acid.
Boc-6-AMinocaproic acid Preparation Products And Raw materials
Preparation ProductsN-BOC-1,6-diaminohexane-->1,8-diazacyclotetradecane-2,9-dione-->METHYL 6-AMINOCAPROATE HYDROCHLORIDE-->6-(BOC-AMINO)-HEXYL BROMIDE
N-Benzyloxycarbonyl-N'-(tert-Butoxycarbonyl)-L-lysine N-alpha-FMOC-Nepsilon-BOC-L-Lysine BOC-LYS(BOC)-ONP Boc-Lys(Boc)-OH FMOC-LYS(BOC)(ISOPROPYL)-OH BOC-LYS(BOC)-OH DCHA (R)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID,N-ALPHA-T-BUTYLOXYCARBONYL-D-NORLEUCINE, (R)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID N,N'-Di-Boc-L-lysine hydroxysuccinimide ester Boc-6-AMinocaproic acid BOC-D-LYS(BOC)-OH Z-LYS(BOC)-OSU Ne-Boc-L-lysine N-epsilon-Boc-D-lysine Z-LYS(BOC)-OH N-Boc-L-lysine methyl ester hydrochloride FMOC-LYS(BOC)-OPFP Z-LYS(BOC)-ONP Ne-Boc-L-lysine tert-butyl ester hydrochloride

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