ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Antifungal Drugs GRAMICIDIN A

GRAMICIDIN A

GRAMICIDIN A Basic information
Product Name:GRAMICIDIN A
Synonyms:OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH;OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONHCH2CH2OH;HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH;HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH;HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH;GRAMICIDIN A;GRAMICIDIN A, BACILLUS BREVIS;GRIMICIDIN A
CAS:11029-61-1
MF:C99H140N20O17
MW:1882.29
EINECS:234-259-8
Product Categories:Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Mechanism of Action;Peptides;Spectrum of Activity
Mol File:11029-61-1.mol
GRAMICIDIN A Structure
GRAMICIDIN A Chemical Properties
storage temp. 2-8°C
solubility ethanol: soluble
form White to off-white solid
color colorless or white
BRN 6461131
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
RTECS MD8230000
Toxicitymouse,LD50,intraperitoneal,60mg/kg (60mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 240, 1980.
MSDS Information
GRAMICIDIN A Usage And Synthesis
UsesGramicidin A is an effective antibiotic against Gram positive organisms.
Purification MethodsPurify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]
GRAMICIDIN A Preparation Products And Raw materials
des(ethanolamine)taurine(16)-gramicidin A diagnosis latex microsphors combining anti fetoprotein AFP Strip (4,4'-dehydrophenylalanine)gramicidin S gramicidin A, Leu(2)- [Val1]gramicidin A,Gramicidin A 1-L-Val gramicidin(micro) usp23, Gramicidin S2 POLY-L-HISTIDINE GRAMICIDIN A AFP (Alpha Fetoprotein) ELISA gramicidin A, 7-alanine- gramicidin A, 7,8-des-Val- Gramicidin S3 GRAMICIDIN C FROM BACILLUS BREVIS gramicidin-S-synthetase 2 AFP Casset [L-α-Aminomyristic acid3,3']gramicidin S
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