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| | Sennoside A Basic information |
| Product Name: | Sennoside A | | Synonyms: | Sennoside A std.;SENNOSIDEA60%;SENNOSIDE A(P);SENNOSIDE A(SH);SENNOSIDA;CALCIUM SENNOSIDE 5%, 10%, 20%, 60%;[9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'R)-;Sennoside A1 | | CAS: | 81-27-6 | | MF: | C42H38O20 | | MW: | 862.74 | | EINECS: | 201-339-9 | | Product Categories: | The group of Sennosides;Anthraquinones, Hydroquinones and Quinones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors | | Mol File: | 81-27-6.mol |  |
| | Sennoside A Chemical Properties |
| Melting point | >191oC (dec.) | | alpha | D20 -164° (c = 0.1 in 60% acetone); D20 -147° (c = 0.1 in 70% acetone); D20 -24° (c = 0.2 in 70% dioxane) | | Boiling point | 1144.8±65.0 °C(Predicted) | | density | 1.743±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated) | | form | neat | | pka | 3.31±0.40(Predicted) | | color | Yellow to Dark Yellow | | BRN | 5723746 | | Stability: | Hygroscopic | | InChIKey | IPQVTOJGNYVQEO-KGFNBKMBSA-N | | LogP | 1.880 (est) |
| Risk Statements | 22 | | Safety Statements | 22-45 | | WGK Germany | 3 | | F | 3-10 | | HS Code | 29173990 |
| | Sennoside A Usage And Synthesis |
| Chemical Properties | Light yellow powder | | Uses | a natural anthroquinonone glucoside calcium complex with laxative properties | | Uses | Sennoside A is used as a laxative in the treatment of constipation. In addition. it is hypothesized to induce cell proliferation and may be a potential carcinogenic agent. | | Definition | ChEBI: Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. It is a member of sennosides and an oxo dicarboxylic acid. | | Purification Methods | Sennoside A (bianthraquinonyl-bis-glucoside R,R-enantiomer) [81-27-6] M 862.7, m 220 -2 4 0o(dec), [ ] D -164o (c 0.1, Me2CO/H2O 6:4), [ ] D -24o (c 0.2, 70% aqueous dioxane). Sennoside A forms yellow crystals from aqueous acetone, 2-ethoxyethanol or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3403.] |
| | Sennoside A Preparation Products And Raw materials |
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