|
| | (±)-trans-GK563 Basic information |
| | (±)-trans-GK563 Chemical Properties |
| Boiling point | 364.2±11.0 °C(Predicted) | | density | 1.010±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble |
| | (±)-trans-GK563 Usage And Synthesis |
| Description | trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells. | | References | 1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis J. Med. Chem. 62(6),2916-2927(2019). |
| | (±)-trans-GK563 Preparation Products And Raw materials |
|
