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| | TYRPHOSTIN AG 1024 Basic information |
| Product Name: | TYRPHOSTIN AG 1024 | | Synonyms: | AG1024; TYRPHOSTIN AG 1024;AG 1024 - CAS 65678-07-1 - Calbiochem;CS-241;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AGS 200;Tyrphostin;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200;AG-1024;HY-10253; AG 1024; AGS 200 | | CAS: | 65678-07-1 | | MF: | C14H13BrN2O | | MW: | 305.17 | | EINECS: | | | Product Categories: | | | Mol File: | 65678-07-1.mol |  |
| | TYRPHOSTIN AG 1024 Chemical Properties |
| storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: soluble | | form | solid | | color | yellow |
| | TYRPHOSTIN AG 1024 Usage And Synthesis |
| Description | The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM. | | Uses | Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist. | | Definition | ChEBI: 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile is an alkylbenzene. | | target | IGF-1R | | references | [1] párrizas m1, gazit a, levitzki a, wertheimer e, leroith d. specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. endocrinology. 1997 apr;138(4):1427-33.
[2] fan p1, agboke fa1, mcdaniel re1, sweeney ee1, zou x1, creswell k1, jordan vc2.inhibition of c-src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. eur j cancer. 2014 jan; 50(2):457-68. |
| | TYRPHOSTIN AG 1024 Preparation Products And Raw materials |
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