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Product Name: | Tosyl azide | Synonyms: | Tosyl azide, 30% w/w in toluene;Tosyl azide (75% in ethyl acetate);p-Toluenesulfonazide solution;p-Toluenesulfonyl azide solution11-15 % (w/w) in Toluene,
≥ 99% (HPLC);4-methylbenzene-1-sulfonyl azide;p-Toluenesulfonyl azide, 99%, 25% in Ethyl acetate;4-methyl-benzenesulfonylazid;Benzenesulfonylazide,4-methyl- | CAS: | 941-55-9 | MF: | C7H7N3O2S | MW: | 197.21 | EINECS: | 213-381-5 | Product Categories: | bc0001 | Mol File: | 941-55-9.mol | |
| Tosyl azide Chemical Properties |
| Tosyl azide Usage And Synthesis |
Description | Tosyl azide is a reagent used in organic synthesis. It is prepared by the reaction of tosyl chloride with sodium azide in aqueous acetone.
| Applications | Tosyl azide is utilized for the introduction of diazo and azide functional groups. Moreover, it is used as a nitrene and a substrate for [3+2] cycloaddition reactions.
| Safety | Tosyl azide is a very volatile chemical that should be carefully stored and handled.
| Chemical Properties | Colorless to slight yellow liquid | Uses | Used for the introduction of azide and diazo functional groups. It is also used as a nitrene source and as a substrate for [3+2] cycloaddition reactions. | Uses | 4-Methylbenzenesulfonyl Azide can be used to target Bcl-2 family proteins to potentially treat cancer. | Uses | p-Toluenesulfonyl azide solution can be employed as a reagent along with alkyne, and amine in the three-component coupling reaction for the synthesis of N-sulfonylamidines in presence of copper catalyst. It can also be used in the synthesis of N-sulfonyl-1,2,3-triazoles by azide-alkyne cycloaddition reaction in the presence of copper catalyst. | Synthesis Reference(s) | Synthetic Communications, 17, p. 1015, 1987 DOI: 10.1080/00397918708063962 Tetrahedron Letters, 28, p. 5091, 1987 DOI: 10.1016/S0040-4039(00)95598-9 |
| Tosyl azide Preparation Products And Raw materials |
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