NICOTINIC ACID HYDRAZIDE

NICOTINIC ACID HYDRAZIDE Basic information

Product Name:	NICOTINIC ACID HYDRAZIDE
Synonyms:	LABOTEST-BB LT01593663;(3-pyridylcarbonyl)hydrazine;3-Pyridinecarboxylic acid, hydrazide;3-Pyridinecarboxylic hydrazide;3-pyridinecarboxylicacid,hydrazide;3-Pyridoyl Hydrazine;3-pyridoylhydrazine;3-Pyridylcarbonylhydrazine
CAS:	553-53-7
MF:	C6H7N3O
MW:	137.14
EINECS:	209-041-0
Product Categories:	Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds;AMIDE
Mol File:	553-53-7.mol

NICOTINIC ACID HYDRAZIDE Chemical Properties

Melting point	159-161 °C(lit.)
Boiling point	251.97°C (rough estimate)
density	1.2620 (rough estimate)
refractive index	1.6910 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	H2O: soluble50mg/mL
pka	11.43±0.10(Predicted)
form	Fine Needle-Like Crystalline Powder
color	White to off-white
Water Solubility	Soluble in alcohol, water.
BRN	119299
InChIKey	KFUSANSHCADHNJ-UHFFFAOYSA-N
CAS DataBase Reference	553-53-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-26-36/37/39
RIDADR	UN2811
WGK Germany	3
RTECS	QT1750000
HazardClass	6.1
PackingGroup	III
HS Code	29280000
Toxicity	LD50 intravenous in mouse: 180mg/kg

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

NICOTINIC ACID HYDRAZIDE Usage And Synthesis

Chemical Properties	WHITE TO OFF-WHITE FINE NEEDLE-LIKE CRYST. POWDER
Uses	Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.
Uses	An Impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.
Biochem/physiol Actions	Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.
Purification Methods	Crystallise it from aqueous EtOH or *benzene. [Beilstein 22 III/IV 439, 22/2 V 121.]

NICOTINIC ACID HYDRAZIDE Preparation Products And Raw materials

Raw materials	Methanol-->Hydrazinium hydroxide solution-->Methyl nicotinate
Preparation Products	Pikamilone-->3-Pyridinecarboxamide, N-propyl--->Ethyl 5-(pyridin-3-yl)-1,3,4-oxadiazole-2-carboxylate-->SODIUM 5-(PYRIDIN-3-YL)-1,3,4-THIADIAZOLE-2-CARBOXYLATE-->4-ETHYL-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL

1-(4-FLUOROPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE 2-(2,6-DICHLOROBENZYL)-1-PHENYL-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE N'3-(5-CHLORO-1-METHYL-6-OXO-1,6-DIHYDROPYRIDAZIN-4-YL)-N'3-METHYL-2-CHLOROPYRIDINE-3-CARBOHYDRAZIDE 1-(4-CHLOROPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE N'3-([6-CHLORO-4-(TRIFLUOROMETHYL)-3-PYRIDYL]CARBONYL)-6-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOHYDRAZIDE 2-(DIMETHYLAMINO)-1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE 1-(3-CHLOROPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE 2-PIPERIDINO-1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE 4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE AURORA 762 N'3-[(2,6-DICHLORO-4-PYRIDYL)METHYLIDENE]PYRIDINE-3-CARBOHYDRAZIDE AURORA 2781 1-(4-METHYLPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE 2-PHENOXYPYRIDINE-3-CARBOHYDRAZIDE N'3-[(6-CHLORO-3-PYRIDYL)CARBONYL]-4-(2-[(4-CHLOROPHENOXY)METHYL]-1,3-THIAZOL-4-YL)-5-METHYLISOXAZOLE-3-CARBOHYDRAZIDE 2-(4-CHLOROBENZYL)-1-PHENYL-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE N'3-[(6-CHLORO-3-PYRIDYL)CARBONYL]-5-METHYL-4-[2-(PHENOXYMETHYL)-1,3-THIAZOL-4-YL]ISOXAZOLE-3-CARBOHYDRAZIDE N'9-[(2-CHLORO-3-PYRIDYL)CARBONYL]-9H-XANTHENE-9-CARBOHYDRAZIDE

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