ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Leucine derivatives Fmoc-Leu-OH

Fmoc-Leu-OH

Fmoc-Leu-OH Basic information
Product Name:Fmoc-Leu-OH
Synonyms:FMOC-L-LEU;FMOC-L-LEUCINE;F-L-LEU;Fmoc-L-leucine,98%;L-Leucine-1-13C-N-FMOC;Fmoc-N-(isobutyl)-glycine;FMOC-L-LEU-OH MONOHYDRATE;Fmoc-N-(isobutyl)-Gly-OH
CAS:35661-60-0
MF:C21H23NO4
MW:353.41
EINECS:252-662-7
Product Categories:Imidazoles ,Homopiperidines;Leucine [Leu, L];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series;Protected Amino Acids;Fluorenes, Flurenones;AMINOACIDS DERIVATIVES;Amino Acid Derivatives;Amino Acids;Prostanoid receptor and related;35661-60-0
Mol File:35661-60-0.mol
Fmoc-Leu-OH Structure
Fmoc-Leu-OH Chemical Properties
Melting point 152-156 °C(lit.)
alpha -26 º (c=1,DMF 24 ºC)
Boiling point 486.83°C (rough estimate)
density 1.2107 (rough estimate)
refractive index -25 ° (C=1, DMF)
storage temp. Store below +30°C.
solubility DMF (Slightly), DMSO (Slightly)
form Solid
pka3.91±0.21(Predicted)
color White to Off-White
optical activity[α]20/D 25±2°, c = 1% in DMF
BRN 2178254
Stability:Hygroscopic
InChIKeyCBPJQFCAFFNICX-IBGZPJMESA-N
CAS DataBase Reference35661-60-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36/37/39-27-26
WGK Germany 3
HS Code 2924 29 70
MSDS Information
ProviderLanguage
N-(9-Fluorenylmethoxycarbonyl)-L-leucine English
SigmaAldrich English
ACROS English
ALFA English
Fmoc-Leu-OH Usage And Synthesis
DescriptionFmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.
Chemical Propertieswhite to light yellow crystal powde
UsesFmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.
ApplicationFmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.
PreparationFmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.
Biological ActivityAnti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.
Fmoc-Leu-OH Preparation Products And Raw materials
Raw materialsFMOC-b-Ala-OH
Preparation ProductsINDOLICIDIN-->ANGIOTENSIN I, HUMAN-->MELITTIN-->FMOC-L-BETA-HOMOLEUCINE-->FMOC-LEU-ONP-->FMOC-L-LEUCYL CHLORIDE-->Fmoc-N-methyl-L-leucine
N-ALPHA-FMOC-L-LEUCINE (C1-13C) N-FMOC-L-LEUCINE, [4,5-3H] (2S,4S)-FMOC-4-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-[15N]LEU-OH Leucine aminopeptidase，porcine kidney FMOC-OIC-OH Fmoc-Aib-OH N-ALPHA-FMOC-BETA-(1-BOC-PIPERIDIN-4-YL)-D,L-ALANINE FMOC-L-CYCLOPROPYLALANINE Fmoc-N-methyl-L-leucine N-FMOC-D-LEUCINE, [1-14C],N-FMOC-L-LEUCINE, [14C(U)]-,N-FMOC-L-LEUCINE, [1-14C] FMOC-CHA-OH N-ALPHA-FMOC-L-LEUCINE P-NITROPHENYL ESTER,FMOC-L-LEUCINE 4-NITROPHENYL ESTER NALPHA-9-Fluorenylmethoxycarbonyl-L-leucine N-carboxylic anhydride FMOC-LEU-2-CL-TRT RESIN Fmoc FMOC-L-LEUCINE HYDROXYSUCCINIMIDE ESTER,FMOC-L-LEUCINE N-HYDROXYSUCCINIMIDE ESTER,FMOC-L-LEUCINE HYDROXYSUCCINIMIDESTER FMOC-L-LEUCINE PENTAFLUOROPHENYL ESTER,N-ALPHA-FMOC-L-LEUCINE PENTAFLUOROPHENYL ESTER
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