ChemicalBook Product Catalog Biochemical Engineering Nucleoside drugs Nucleotides and their analogs 6-Methylthioguanine

6-Methylthioguanine

6-Methylthioguanine Basic information
Product Name:6-Methylthioguanine
Synonyms:1H-Purin-2-amine, 6-(methylthio)-;2-Amino-6-methylthiopurine;6-(Methylsulfanyl)-1H-purin-2-amine;6-Methylthioguanine;TIMTEC-BB SBB000228;6-(METHYLSULFANYL)-7H-PURIN-2-YLAMINE;2-AMINO-6-METHYLMERCAPTOPURINE;2-AMINO-6-METHYLMERCAPTOPURINE 95%
CAS:1198-47-6
MF:C6H7N5S
MW:181.22
EINECS:214-833-4
Product Categories:Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Mutagenesis Research Chemicals, Sulfur & Selenium Compounds;Bases & Related Reagents;Heterocycles;Metabolites & Impurities;Mutagenesis Research Chemicals;Nucleotides;Sulfur & Selenium Compounds
Mol File:1198-47-6.mol
6-Methylthioguanine Structure
6-Methylthioguanine Chemical Properties
Melting point 235.5°C
density 1.403 (estimate)
refractive index 1.4606 (estimate)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
form solid
color White to Off-White
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 24/25-39-26
WGK Germany 3
HS Code 29335995
MSDS Information
ProviderLanguage
ACROS English
6-Methylthioguanine Usage And Synthesis
Chemical Propertiesoff-white crystalline powder
UsesAs a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
Uses2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.
DefinitionChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine.
Biochem/physiol Actions2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.
6-Methylthioguanine Preparation Products And Raw materials
Preparation Products7-METHYLGUANINE
2-AMINO-9-(2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)-6-THIOPURINE 1,9-DIHYDRO-6H-PURINE-6-THIONE 6-N-HEPTYLMERCAPTOPURINE 2-Amino-6-mercaptopurine-13C2,15N 6,8-DIHYDROXY-2-METHYLMERCAPTOPURINE 6-(Methylthio)purine 6-thioinosine-5'-triphosphate GUANERAN 6-[(phenylmethyl)thio]-1H-purin-2-amine S-(2-HYDROXY-5-NITROBENZYL)-6-THIOGUANOSINE alamifovir 6-Methylthioguanine 2-AMINO-6-CHLORO-[(4-METHYLPHENYL)THIO]-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE 2-AMINO-6-CARBOXYMETHYLMERCAPTOPURINE NBTGR 6-[(4-FLUOROPHENYL)SULFANYL]-9H-PURIN-2-AMINE 6-THIO-G CEP 6-THIO-DG CEP
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